[Determination of platinum anticancer drugs in occupational settings by ICP-MS]

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2022 Dec 20;40(12):950-951. doi: 10.3760/cma.j.cn121094-20220222-00083.
[Article in Chinese]

Abstract

Objective: To establish an inductively coupled plasma mass spectrometry (ICP-MS) for platinum antineoplastic drugs in the environment. Methods: The platinum antineoplastic drugs in the environmental table were eluted by wiping and collecting pure water, and the supernatant was taken by centrifugation and inductively coupled plasma mass spectrometry for detection. Results: The concentration range of 0-8.0 μg/L was good, the correlation coefficient was 1.000, the detection limit was 0.0006 μg/L, the lower quantitative limit was 0.002 μg/L, the method precision was between 0.9%-1.3%, and the sample standard recovery rate was between 97.0%-98.5%. Conclusion: This method has low detection limit, high accuracy and precision, and simple sample pretreatment, which is suitable for the determination of platinum antineoplastic drugs in environmental tables.

目的: 建立环境中铂类抗癌药物的感应耦合等离子体质谱法(ICP-MS)测定方法。 方法: 环境物表中的铂类抗癌药物经擦拭采集纯水洗脱,离心取上清进电感耦合等离子体质谱进行检测。 结果: 本方法测定浓度范围在0~8.0 μg/L内线性范围良好,相关系数为1.000,方法检出限为0.0006 μg/L,定量下限为0.002 μg/L,方法精密度在0.9%~1.3%,样品加标回收率在97.0%~98.5%。 结论: 本方法对铂类抗癌药物测定检出限低,准确度、精密度高,样品前处理简单,适用于环境物表中的铂类抗癌药物的测定。.

Keywords: Environment; ICP-MS, Environmental table; Object surface; Platinum antineoplastic drugs.

Publication types

  • English Abstract

MeSH terms

  • Antineoplastic Agents*
  • Mass Spectrometry / methods
  • Platinum* / analysis
  • Platinum* / chemistry
  • Spectrum Analysis

Substances

  • Platinum
  • Antineoplastic Agents