Elevated serum AST and LDH levels are associated with infant death in premature babies with neonatal leukemoid reaction: a cohort study

Ruibo Liu; Yuwen Huang; Zhifang Jia; Mary Joseline Joseph; Kening Chai; Tianhui Xiong; Wei Zhou; Linlin Qu; Wei Xia

doi:10.21037/tp-22-543

Elevated serum AST and LDH levels are associated with infant death in premature babies with neonatal leukemoid reaction: a cohort study

Transl Pediatr. 2022 Dec;11(12):1920-1927. doi: 10.21037/tp-22-543.

Authors

Ruibo Liu^{1

2}, Yuwen Huang¹, Zhifang Jia³, Mary Joseline Joseph¹, Kening Chai^{1

2}, Tianhui Xiong^{1

2}, Wei Zhou^{1

2}, Linlin Qu¹, Wei Xia²

Affiliations

¹ Department of Laboratory Medicine, the First Hospital of Jilin University, Changchun, China.
² College of Medical Technology, Beihua University, Jilin, China.
³ Division of clinical epidemiology, the First Hospital of Jilin University, Changchun, China.

Abstract

Background: Neonatal leukemoid reaction (NLR) is often accompanied by infectious or non-infectious diseases, a low birth weight, sepsis, prematurity, ventricular hemorrhage, and bronchial dysplasia. It has an incidence rate of 1.3-15% and a mortality rate of about 41.4%. Previous studies on NLR have largely focused on its pathogenesis and clinical cases, but little is known about its prognostic laboratory indicators. We found that some of the NLR exhibited obviously elevation in liver function tests like aspartate transaminase (AST) and lactate dehydrogenase (LDH) which were not took by all the LR infants. The necessity for liver function tests for the prognosis of NLR was still unclear.

Methods: A total of 39 premature infants with NLR at the First Hospital of Jilin University between March 2016 and March 2017 were included in this retrospective cohort study. The infants were divided into death and cured group based on the clinical outcomes. Premature infants with LR and death were defined as the case group (n=14), while infants without death were defined as the control group (n=25). Confounding factors such as age and gender between the two groups were controlled. Blood routine tests, including the white blood cell (WBC) count and subtypes, and liver function, and clinical features were recorded and analyzed. T tests were used to examine the differences in the laboratory indicators between the NLR and control groups. Receiver operating characteristic curves (ROCs) and areas under the curve (AUCs) were used to examine laboratory indicators for prognosis.

Results: For predicting clinical outcomes, the ROC curves showed that the cut-off values for AST and LDH were 279 and 1,412 U/L, respectively. The sensitivity and specificity for AST were 92% and 71.43%, respectively, with an AUC of 0.894, while the sensitivity and specificity for LDH were 88% and 78.57%, respectively, with an AUC of 0.911.

Conclusions: This innovative study investigated the NLR prognosis depending on laboratory tests. We found that serum AST and LDH levels had reliable predictive value in determining adverse outcomes of NLR.

Keywords: Neonatal leukemoid reaction; aspartate transaminase (AST); laboratory medicine; lactate dehydrogenase (LDH); prognosis.