Emerging implications for ribosomes in proximity to mitochondria

Bar Cohen; Adi Golani-Armon; Yoav S Arava

doi:10.1016/j.semcdb.2023.01.003

Emerging implications for ribosomes in proximity to mitochondria

Semin Cell Dev Biol. 2024 Feb 15;154(Pt B):123-130. doi: 10.1016/j.semcdb.2023.01.003. Epub 2023 Jan 13.

Authors

Bar Cohen¹, Adi Golani-Armon¹, Yoav S Arava²

Affiliations

¹ Faculty of Biology, Technion - Israel Institute of Technology, Haifa 3200003, Israel.
² Faculty of Biology, Technion - Israel Institute of Technology, Haifa 3200003, Israel. Electronic address: arava@technion.ac.il.

PMID: 36642616
DOI: 10.1016/j.semcdb.2023.01.003

Abstract

Synthesis of all proteins in eukaryotic cells, apart from a few organellar proteins, is done by cytosolic ribosomes. Many of these ribosomes are localized in the vicinity of the functional site of their encoded protein, enabling local protein synthesis. Studies in various organisms and tissues revealed that such locally translating ribosomes are also present near mitochondria. Here, we provide a brief summary of evidence for localized translation near mitochondria, then present data suggesting that these localized ribosomes may enable local translational regulatory processes in response to mitochondria needs. Finally, we describe the involvement of such localized ribosomes in the quality control of protein synthesis and mitochondria. These emerging views suggest that ribosomes localized near mitochondria are a hub for a variety of activities with diverse implications on mitochondria physiology.

Keywords: Localized translation; MitoRQC; Mitochondria; RNA binding proteins; Ribosomal quality control; Ribosomes; Translation regulation; mRNA localization.

Publication types

Review