The microbiota, the malarial parasite, and the mosquito [MMM] - A three-sided relationship

Abstract

The mosquito gut microbiota is vital to the proper functioning of the host organism. Mosquitoes may benefit from this microbiota in their guts because it promotes factors including blood digestion, fecundity, metamorphosis, and living habitat and inhibits malarial parasites (Plasmodium) growth or transmission. In this overview, we analyzed how mosquitoes acquire their gut microbiota, characterized those bacteria, and discussed the functions they provide. We also investigated the effects of microbiota on malaria vectors, with a focus on the mosquito species Anopheles, as well as the relationship between microbiota and Plasmodium, the aspects in which microbiota influences Plasmodium via immune response, metabolism, and redox mechanisms, and the strategies in which gut bacteria affect the life cycle of malaria vectors and provide the ability to resist insecticides. This article explores the difficulties in studying triadic interactions, such as the interplay between Mosquitoes, Malarial parasite, and the Microbiota that dwell in the mosquitoes' guts, and need additional research for a better understanding of these multiple connections to implement an exact vector control strategies using Gut microbiota in malaria control.

Keywords: Anopheles; Gut microbiota; Immune response; Mosquitoes; Plasmodium.