Multi-model adaptive fusion-based graph network for Alzheimer's disease prediction

Abstract

Alzheimer's disease (AD) is a common cognitive disorder. Recently, many computer-aided diagnostic techniques have been used for AD prediction utilizing deep learning technology, among which graph neural networks have received increasing attention owing to their ability to model sample relationships on large population graphs. Most of the existing graph-based methods predict diseases according to a single model, which makes it difficult to select an appropriate node embedding algorithm for a certain classification task. Moreover, integrating data from different patterns into a unified model to improve the quality of disease diagnosis remains a challenge. Hence, in this study, we aimed to develop a multi-model fusion framework for AD prediction. A spectral graph attention model was used to aggregate intra- and inter-cluster node embeddings of normal and diseased populations, whereafter, a bilinear aggregation model was applied as an auxiliary model to enhance the abnormality degree in different categories of populations, and finally, an adaptive fusion module was designed to dynamically fuse the results of both models and enhance AD prediction. Compared to other comparison methods, the model proposed in this study provides the best results.

Keywords: Alzheimer's disease prediction; Computational medicine; Disease prediction algorithm; Multi-model fusion.