A copper-metal organic framework enhances the photothermal and chemodynamic properties of polydopamine for melanoma therapy

Lidan Liu; Haifeng Zhang; Luxi Peng; Donghui Wang; Yu Zhang; Bangcheng Yan; Juning Xie; Shun Xing; Feng Peng; Xuanyong Liu

doi:10.1016/j.actbio.2023.01.010

A copper-metal organic framework enhances the photothermal and chemodynamic properties of polydopamine for melanoma therapy

Acta Biomater. 2023 Mar 1:158:660-672. doi: 10.1016/j.actbio.2023.01.010. Epub 2023 Jan 11.

Authors

Lidan Liu¹, Haifeng Zhang², Luxi Peng³, Donghui Wang⁴, Yu Zhang⁵, Bangcheng Yan¹, Juning Xie⁵, Shun Xing¹, Feng Peng⁶, Xuanyong Liu⁷

Affiliations

¹ State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China; Center of Materials Science and Optoelectronics Engineering, University of Chinese, Academy of Sciences, Beijing 100049, China.
² State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China; Center of Materials Science and Optoelectronics Engineering, University of Chinese, Academy of Sciences, Beijing 100049, China; School of Chemistry and Materials Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, 1 Sub-lane Xiangshan, Hangzhou 310024, China.
³ Department of Pharmacy, Zhongshan Hospital, Fudan University, Shanghai 200050, China.
⁴ School of Health Sciences and Biomedical Engineering, Hebei University of Technology, Tianjin 300130, China.
⁵ Medical Research Institute, Department of Orthopedics, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou 510080, China.
⁶ Medical Research Institute, Department of Orthopedics, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou 510080, China. Electronic address: pengfeng@gdph.org.cn.
⁷ State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China; Center of Materials Science and Optoelectronics Engineering, University of Chinese, Academy of Sciences, Beijing 100049, China; School of Chemistry and Materials Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, 1 Sub-lane Xiangshan, Hangzhou 310024, China. Electronic address: xyliu@mail.sic.ac.cn.

PMID: 36640955
DOI: 10.1016/j.actbio.2023.01.010

Abstract

The combination of photothermal treatment and chemodynamic therapy has attracted extensive attention for improving therapeutic effects and compensating the insufficiency of monotherapy. In this work, a copper-metal organic framework (Cu-BTC) was used to augment the photothermal effect of polydopamine (PDA) and endow it with a chemodynamic ability by constructing a Cu-BTC@PDA nanocomposite. Density functional theory calculations revealed that the plasmonic vibrations formed by the d-d transition of Cu at the Fermi level in Cu-BTC@PDA could enhance the photothermal performance of PDA. In addition, more Cu²⁺ released from Cu-BTC@PDA in the acidic microenvironment of the tumor was then reduced to Cu⁺ by glutathione (GSH) and further catalyzed H₂O₂ to generate more toxic hydroxyl radical (•OH), which synergized with photothermal treatment for melanoma therapy. Furthermore, Cu-BTC@PDA could quickly and effectively kill bacteria under the action of PTT, and the sustained release of Cu ions could contribute to the long-term and stable bacteriostatic ability of the material. This sustained release of Cu ions could also promote the cell migration and angiogenesis, and upregulate the expression of COL-, TGF-, and VEGF-related genes to accelerate wound healing. This multifunctional nanomaterial has potential application in the treatment of melanoma and repair of wounds. STATEMENT OF SIGNIFICANCE: We constructed a multifunctional nanoplatform (Cu-BTC@PDA) by two steps. This nanoplatform can not only perform cascade catalysis in the tumor microenvironment to generate more toxic hydroxyl radical (•OH), but also synergize with photothermal treatment for melanoma therapy. Additionally, Cu-BTC@PDA possesses enhanced photothermal performance through the plasmonic vibrations formed by the d-d transition of Cu at the Fermi level in Cu-BTC@PDA, which is revealed by DFT calculations. And Cu-BTC@PDA shows good antitumor, antibacterial, and wound healing properties in vivo and in vitro. Such a multifunctional nanomaterial has potential application in the treatment of melanoma and repair of wounds.

Keywords: Antibacterial; Antitumor; Chemodynamic therapy; Photothermal enhancement; Wound healing.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cell Line, Tumor
Copper / pharmacology
Delayed-Action Preparations
Glutathione
Humans
Hydrogen Peroxide
Hydroxyl Radical
Melanoma* / drug therapy
Metal-Organic Frameworks* / pharmacology
Nanoparticles*
Tumor Microenvironment

Substances

Copper
Delayed-Action Preparations
Glutathione
Hydrogen Peroxide
Hydroxyl Radical
Metal-Organic Frameworks
polydopamine