Outcomes of the 2019 hydrocephalus association workshop, "Driving common pathways: extending insights from posthemorrhagic hydrocephalus"

Jason K Karimy; Jessie C Newville; Cameron Sadegh; Jill A Morris; Edwin S Monuki; David D Limbrick Jr; James P McAllister Ii; Jenna E Koschnitzky; Maria K Lehtinen; Lauren L Jantzie

doi:10.1186/s12987-023-00406-7

Outcomes of the 2019 hydrocephalus association workshop, "Driving common pathways: extending insights from posthemorrhagic hydrocephalus"

Fluids Barriers CNS. 2023 Jan 13;20(1):4. doi: 10.1186/s12987-023-00406-7.

Authors

Affiliations

¹ Department of Family Medicine, Mountain Area Health Education Center - Boone, North Carolina, 28607, USA.
² Department of Pediatrics and Neurosurgery, Johns Hopkins Children's Center, Johns Hopkins School of Medicine, Baltimore, MD, 21287, USA.
³ Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, MA, Boston, 02114, USA.
⁴ Department of Pathology, Boston Children's Hospital, Boston, MA, 02115, USA.
⁵ National Institute of Neurological Disorders and Stroke, Neuroscience Center, National Institutes of Health, 6001 Executive Blvd, NSC Rm 2112, Bethesda, MD, 20892, USA.
⁶ Departments of Pathology & Laboratory Medicine and Developmental & Cell Biology, University of California Irvine, Irvine, CA, 92697, USA.
⁷ Departments of Neurosurgery and Pediatrics, Washington University School of Medicine in St. Louis, St. Louis, MO, 63110, USA.
⁸ Hydrocephalus Association, Bethesda, MD, 20814, USA.
⁹ Department of Pathology, Boston Children's Hospital, Boston, MA, 02115, USA. Maria.Lehtinen@childrens.harvard.edu.
¹⁰ Department of Pediatrics and Neurosurgery, Johns Hopkins Children's Center, Johns Hopkins School of Medicine, Baltimore, MD, 21287, USA. LJantzie@jhmi.edu.
¹¹ Kennedy Krieger Institute, Baltimore, MD, 21287, USA. LJantzie@jhmi.edu.

Abstract

The Hydrocephalus Association (HA) workshop, Driving Common Pathways: Extending Insights from Posthemorrhagic Hydrocephalus, was held on November 4 and 5, 2019 at Washington University in St. Louis. The workshop brought together a diverse group of basic, translational, and clinical scientists conducting research on multiple hydrocephalus etiologies with select outside researchers. The main goals of the workshop were to explore areas of potential overlap between hydrocephalus etiologies and identify drug targets that could positively impact various forms of hydrocephalus. This report details the major themes of the workshop and the research presented on three cell types that are targets for new hydrocephalus interventions: choroid plexus epithelial cells, ventricular ependymal cells, and immune cells (macrophages and microglia).

Keywords: Cerebrospinal fluid; Cilia; Ependyma; Germinal matrix hemorrhage; Hydrocephalus; Intraventricular hemorrhage; Post-infectious; Posthemorrhagic.

Publication types

Review

MeSH terms

Cerebral Hemorrhage* / metabolism
Choroid Plexus / metabolism
Humans
Hydrocephalus*

Grants and funding

P50 HD105351/HD/NICHD NIH HHS/United States