Marine life as a source for breast cancer treatment: A comprehensive review

Amjad Hussain; Marie-Lise Bourguet-Kondracki; Maryam Majeed; Muhammad Ibrahim; Muhammad Imran; Xian-Wen Yang; Ishtiaq Ahmed; Ataf Ali Altaf; Anees Ahmed Khalil; Abdur Rauf; Polrat Wilairatana; Hassan A Hemeg; Riaz Ullah; Ivan R Green; Iftikhar Ali; Syed Tasadaque A Shah; Hidayat Hussain

doi:10.1016/j.biopha.2022.114165

Marine life as a source for breast cancer treatment: A comprehensive review

Biomed Pharmacother. 2023 Mar:159:114165. doi: 10.1016/j.biopha.2022.114165. Epub 2023 Jan 10.

Authors

Amjad Hussain¹, Marie-Lise Bourguet-Kondracki², Maryam Majeed³, Muhammad Ibrahim³, Muhammad Imran⁴, Xian-Wen Yang⁵, Ishtiaq Ahmed⁶, Ataf Ali Altaf⁷, Anees Ahmed Khalil⁸, Abdur Rauf⁹, Polrat Wilairatana¹⁰, Hassan A Hemeg¹¹, Riaz Ullah¹², Ivan R Green¹³, Iftikhar Ali¹⁴, Syed Tasadaque A Shah¹⁵, Hidayat Hussain¹⁶

Affiliations

¹ Department of Chemistry University of Okara, Okara, Pakistan; Laboratoire Molécules de Communication et Adaptation des Micro-organismes, UMR 7245 MNHN-CNRS, Muséum National d'Histoire Naturelle, 57 rue Cuvier (C.P. 54), 75005 Paris, France. Electronic address: amjadhussain@uo.edu.pk.
² Laboratoire Molécules de Communication et Adaptation des Micro-organismes, UMR 7245 MNHN-CNRS, Muséum National d'Histoire Naturelle, 57 rue Cuvier (C.P. 54), 75005 Paris, France.
³ Department of Applied Chemistry, Government College University, Faisalabad, Pakistan.
⁴ Department of chemistry, Faculty of Science, Research center for Advanced Materials Science (RCAMS), King Khalid University, P.O. Box 9004, Abha 61413, Saudi Arabia.
⁵ Key Laboratory of Marine Biogentic Resources, Third Institute of Oceanography, Ministry of Natural Resources, 184 Daxue Road, Xiamen 361005, China.
⁶ Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, UK.
⁷ Department of Chemistry University of Okara, Okara, Pakistan.
⁸ University Institute of Diet and Nutritional Sciences, Faculty of Allied Health Sciences, The University of Lahore, Pakistan.
⁹ Department of Chemistry, University of Swabi Khyber Pukhtanukha, Pakistan.
¹⁰ Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand. Electronic address: polrat.wil@mahidol.ac.th.
¹¹ Department of Medical Laboratory Technology, College of Applied Medical Sciences, Taibah University, Al-Medinah Al-Monawara, Saudi Arabia.
¹² Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
¹³ Department of Chemistry and Polymer Science, University of Stellenbosch, Private Bag X1, Matieland, Stellenbosch 7600, South Africa.
¹⁴ Department of Chemistry, Karakoram International University, Gilgit 15100, Pakistan.
¹⁵ Department of Education, Sukkur IBA University, Sukkur 65200, Sindh, Pakistan.
¹⁶ Leibniz Institute of Plant Biochemistry, Department of Bioorganic Chemistry, Weinberg 3, D-06120 Halle (Saale), Germany. Electronic address: Hussainchem3@gmail.com.

PMID: 36634590
DOI: 10.1016/j.biopha.2022.114165

Abstract

Breast cancer, one of the most significant tumors among all cancer cells, still has deficiencies for effective treatment. Moreover, substitute treatments employing natural products as bioactive metabolites has been seriously considered. The source of bioactive metabolites are not only the most numerous but also represent the richest source. A unique source is from the oceans or marine species which demonstrated intriguing chemical and biological diversity which represents an astonishing reserve for discovering novel anticancer drugs. Notably, marine sponges produce the largest amount of diverse bioactive peptides, alkaloids, terpenoids, polyketides along with many secondary metabolites whose potential is mostly therapeutic. In this review, our main focus is on the marine derived secondary metabolites which demonstrated cytotoxic effects towards numerous breast cancer cells and have been isolated from the marine sources such as marine sponges, cyanobacteria, fungi, algae, tunicates, actinomycetes, ascidians, and other sources of marine organisms.

Keywords: Actinomycetes; Algae; Ascidians; Breast cancer; Cyanobacteria; Fungi; Marine natural products; Sponges; Tunicates.

Publication types

Review

MeSH terms

Animals
Antineoplastic Agents* / chemistry
Antineoplastic Agents* / pharmacology
Antineoplastic Agents* / therapeutic use
Aquatic Organisms / chemistry
Biological Products* / chemistry
Neoplasms* / drug therapy
Porifera* / chemistry

Substances

Antineoplastic Agents
Biological Products