MiRNA regulated therapeutic potential of the stromal vascular fraction: Current clinical applications - A systematic review

Murad Agaverdiev; Bedil Shamsov; Sorbon Mirzoev; Andranik Vardikyan; Manuel Encarnacion Ramirez; Renat Nurmukhametov; Aferin Beilerli; Bohan Zhang; Ilgiz Gareev; Valentin Pavlov

doi:10.1016/j.ncrna.2022.12.003

MiRNA regulated therapeutic potential of the stromal vascular fraction: Current clinical applications - A systematic review

Noncoding RNA Res. 2022 Dec 19;8(2):146-154. doi: 10.1016/j.ncrna.2022.12.003. eCollection 2023 Jun.

Affiliations

¹ Department of Urology, Bashkir State Medical University, 450008, Ufa, Russian Federation.
² Department of Urology, City Clinical Hospital, №21, 450071, Ufa, Russian Federation.
³ Department of Neurosurgery, Рeoples' Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya Street, Moscow, 117198, Russian Federation.
⁴ Division of Spine Surgery, Central Clinical Hospital of the Russian Academy of Sciences, Moscow, Russian Federation.
⁵ Department of Obstetrics and Gynecology, Tyumen State Medical University, 54 Odesskaya Street, 625023, Tyumen, Russia.
⁶ Department of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, No. 23, Youzheng Street, Harbin, 150001, China.
⁷ Central Research Laboratory, Bashkir State Medical University, 450008, Ufa, Russian Federation.

Abstract

Introduction: The stromal vascular fraction (SVF) is a heterogeneous population of cells that, interacting with each other, can affect the processes of regeneration, angiogenesis, and immunomodulation. Over the past 20 years, there has been a trend towards an increase in the number of clinical studies on the therapeutic use of SVF. MicroRNAs (miRNAs) are also important regulators of cellular function and they have been shown to be involved in SVF cellular component function. The purpose of this study was to analyze existing clinical studies on the therapeutic use of SVF including the role of miRNAs in the regulation of the function of the cellular component of SVF as an anti-inflammatory, pro-angiogenic and cell differentiation activity.

Methods: The search strategy was to use material from the clinicaltrials.gov website, which focused on the key term "Stromal vascular fraction", and the inclusion and exclusion criteria were divided into two stages.

Results: By August 2022, there were 149 registered clinical trials. Most studies belong to either Phase 1-2 (49.37%), Phase 1 (25.32%) or Phase 2 (22.78%). Most of them focused in the fields of traumatology, neurology/neurosurgery, endocrinology, vascular surgery, and immunology. However, only 8 clinical trials had published results. All of clinical trials have similar preparation methods and 8 clinical trials have positive results with no serious adverse effects.

Conclusions: There appears to be a wide potential for the clinical use of SVF without reports of serious side effects. Many preclinical and clinical studies are currently underway on the use of SVF, and their future results will help to further explore their therapeutic potential. Nevertheless, there are not many studies on the role of miRNAs in the SVF microenvironment; however, this topic is very important for further study of the clinical application of SVF, including safety, in various human diseases.

Keywords: Clinical trial; Epidemiology; Stromal vascular fraction; Therapy; miRNA.

Publication types

Review