Modulation of gut microbiota and lipid metabolism in rats fed high-fat diets by Ganoderma lucidum triterpenoids

Aijun Tong; Weihao Wu; Zhengxin Chen; Jiahui Wen; Ruibo Jia; Bin Liu; Hui Cao; Chao Zhao

doi:10.1016/j.crfs.2022.100427

Modulation of gut microbiota and lipid metabolism in rats fed high-fat diets by Ganoderma lucidum triterpenoids

Curr Res Food Sci. 2022 Dec 27:6:100427. doi: 10.1016/j.crfs.2022.100427. eCollection 2023.

Authors

Aijun Tong¹, Weihao Wu¹, Zhengxin Chen¹, Jiahui Wen¹, Ruibo Jia¹, Bin Liu^{1

2}, Hui Cao^{3

4}, Chao Zhao^{5

1}

Affiliations

¹ College of Food Science, Fujian Agriculture and Forestry University, Fuzhou, 350002, China.
² National Engineering Research Center of Juncao, Fujian Agriculture and Forestry University, Fuzhou, 350002, China.
³ College of Food Science and Technology, Guangdong Ocean University, Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Zhanjiang, 524088, China.
⁴ Universidade de Vigo, Nutrition and Bromatology Group, Department of Analytical and Food Chemistry, Faculty of Sciences, 32004, Ourense, Spain.
⁵ College of Marine Sciences, Fujian Agriculture and Forestry University, Fuzhou, 350002, China.

Abstract

Ganoderma lucidum triterpenoids (GP) have been reported to help prevent and improve hyperlipidemia. Modulation of the gut microbiota was proposed as underlying factor as well as a novel measure to prevent and treat hyperlipidemia. The effects of GP on high-fat diet (HFD)-induced hyperlipidemia and gut microbiota modulation were determined in rats. Ultra-performance liquid chromatography tandem quadrupole time-of-flight mass spectrometry (UPLC-QTOF MS-MS) indicated that GP were enriched with ganoderic acids G, B, H, A, and F. After feeding with GP supplementation, serum lipid levels including total triglyceride, total cholesterol, and low-density-lipoprotein cholesterol were significantly decreased in hyperlipidemic rats. Furthermore, administration of GP also has reversed the HFD-induced gut microbiota dysbiosis, including a significant increase in Alloprevotella and reduced proportion of Blautia. The result above suggests that GP would be developed as a functional food to ameliorate lipid metabolic disorders and hyperlipidemia.

Keywords: Fecal; Ganoderma lucidum; Hyperlipidemia; Intestinal contents; Triterpenoids.