The relationship among alcohol, acetaldehyde, and gastric cancer (GC) is a very interesting research direction. Although many studies have focused on the correlation between ALDH2 polymorphism and GC, ALDH2 expression in GC and its relationship with the prognosis of GC patients remain to be fully understood. To explore these, 455 GC cases were included in this study. The relationships of ALDH2 expression with patients' survival and clinicopathological characteristics were assessed. The immune infiltration characteristics of ALDH2 in GC were also analyzed. Furthermore, the gene regulatory network and functional pathways of ALDH2 in GC were investigated. We found that high expression of ALDH2 was associated with better prognosis in GC patients. GC patients with high ALDH2 expression had a lower degree of pathological malignancy, consistent with our hypothesis that ALDH2 may play as a tumor suppressor role in GC. Mechanistically, ALDH2 may cooperate with genes such as C5orf32, TSPAN8 and RILP to inhibit GC progression via regulating multiple signaling pathways and chemical carcinogenesis. Therefore, our study suggested that ALDH2, an important variant gene in Asians, might serve as a prognostic marker and a potential therapeutic target for patients with GC.
Keywords: ALDH2; Gastric cancer; immune infiltration; prognosis; targeted therapy.
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