Angiotensinogen, a promising gene signature for rectum and stomach adenocarcinoma patients

Wei Hu; Mostafa A Abdel-Maksoud; Syed Yousaf Khalid; Abdul Malik; Musaed Alkholief; Ayman Mubarak; Mohammed Aufy

Angiotensinogen, a promising gene signature for rectum and stomach adenocarcinoma patients

Am J Transl Res. 2022 Dec 15;14(12):8879-8892. eCollection 2022.

Authors

Wei Hu¹, Mostafa A Abdel-Maksoud², Syed Yousaf Khalid³, Abdul Malik⁴, Musaed Alkholief⁴, Ayman Mubarak², Mohammed Aufy⁵

Affiliations

¹ The Fourth Clinical Medical College of Yangzhou University, Nantong Rich Hospital Nantong 226010, Jiangsu, China.
² Department of Botany and Microbiology, College of Science, King Saud University P. O. 2455, Riyadh 11451, Saudi Arabia.
³ Department of General Surgery, Letterkenny University Hospital Ireland.
⁴ Department of Pharmaceutics, College of Pharmacy, King Saud University Riyadh, Saudi Arabia.
⁵ Department of Pharmaceutical Sciences, Division of Pharmacology and Toxicology, University of Vienna Vienna, Austria.

PMID: 36628228
PMCID: PMC9827296

Abstract

Objectives: Angiotensinogen (AGT), as a component of the renin-angiotensin system (RAS), is one of the major risk factors for cancer development. To date, there has not been a systematic pan-cancer analysis of AGT.

Methods: This pan-cancer study comprehensively investigated AGT in 24 different cancers based on the UALCAN, KM plotter, GENT2, HPA, MEXPRESS, cBioportal, STRING, TIMER, and CTD databases.

Results: The results showed that AGT was highly expressed in most tumors, and AGT overexpression may be related to the worst survival of Rectum adenocarcinoma (READ) and Stomach Adenocarcinoma (STAD) patients only. Furthermore, pathway analysis indicated that AGT-associated genes are involved in six critical pathways. Moreover, the higher expression of AGT was found to be detrimental to the promoter methylation level (P<0.05), immune cells infiltration (P<0.05), and genetic alterations. We have also predicted various chemotherapeutic drugs contributing to the expression regulation of AGT.

Conclusion: Our results together support that AGT is a possible biomarker for READ and STAD.

Keywords: AGT; READ; STAD; biomarker; diagnostic; prognostic.