From the topics addressed in the articles of this Special Issue, dedicated to acute coronary syndromes (ACS), some priorities have emerged summarizing the complexity of the management of these patients, which must take into account not only clinical and pharmacological factors but also logistical and organizational aspects, as well as elements of health policy. Only the synergy between these different aspects can bring out the solution for the optimization of ACS management, in terms of prevention, diagnosis, treatment and improvement of the patient's quality of life.