Karius With a Q: Role for Microbial Cell-Free DNA Next-Generation Sequencing in Diagnosis of Acute Q Fever

Nischal Ranganath; Ryan B Khodadadi; Omar M Abu Saleh

doi:10.1093/ofid/ofac666

Karius With a Q: Role for Microbial Cell-Free DNA Next-Generation Sequencing in Diagnosis of Acute Q Fever

Open Forum Infect Dis. 2022 Dec 12;10(1):ofac666. doi: 10.1093/ofid/ofac666. eCollection 2023 Jan.

Authors

Nischal Ranganath¹, Ryan B Khodadadi¹, Omar M Abu Saleh¹

Affiliation

¹ Division of Public Health, Infectious Diseases and Occupational Medicine, Mayo Clinic, Rochester, Minnesota, USA.

Abstract

The diagnosis of Q fever can be challenging and a high index of suspicion is necessary. Within this case series, we highlight the utility of the microbial cell-free DNA next-generation sequencing or Karius Test in the timely diagnosis and management of acute Q fever.

Keywords: Coxiella burnetii; Karius test; Q fever; diagnosis; serology.