Domestic dogs as sentinels of children lead exposure: Multi-pathway identification and source apportionment based on isotope technique

Abstract

Environmental lead exposure poses risks to children' health, thus exposure sources and pathways identification remain important concern and research scope. Due to sharing the same environment, domestic animals, especially dogs, have been used as useful sentinels to identify human lead exposure. However, more evidence is needed on whether domestic dogs could be used to identify the lead exposure pathways and sources of children. Thus, this study investigated the dietary habits, behaviors, and household environment of children and dogs in a typical coal-fired area in China. The lead levels and lead isotope ratios (Acronym: LIRs, expressed as ²⁰⁸Pb/²⁰⁶Pb and ²⁰⁷Pb/²⁰⁶Pb) in dogs' and children's blood, as well as in environmental media (food, PM_2.5, indoor/outdoor dust, drinking water and soil) were measured to explore the predominant lead pollution sources and exposure pathways of children. The results showed that the LIRs of children's blood (²⁰⁸Pb/²⁰⁶Pb = 2.0703 ± 0.0076, ²⁰⁷Pb/²⁰⁶Pb = 0.8501 ± 0.0052) were similar to those of dogs' blood (²⁰⁸Pb/²⁰⁶Pb = 2.0696 ± 0.0085, ²⁰⁷Pb/²⁰⁶Pb = 0.8499 ± 0.0052), as well as similar to the LIRs of environmental media, i.e. children's food (²⁰⁸Pb/²⁰⁶Pb = 2.0731 ± 0.0057, ²⁰⁷Pb/²⁰⁶Pb = 0.8491 ± 0.0036) and coal (²⁰⁸Pb/²⁰⁶Pb = 2.0683 ± 0.017, ²⁰⁷Pb/²⁰⁶Pb = 0.8515 ± 0.01). Children and dogs had similar lead exposure pathways, but the contributions of each exposure pathway were different, i.e., 83.1% vs. 76.9% for children and dogs via food ingestion, 1.4% vs. 5.6% via particulate matter exposure, and 15.5% vs. 17.5% via household dust exposure, respectively. The contribution of food via ingestion to lead exposure remains dominant, and coal combustion is a main lead exposure source for children and domestic dogs.

Keywords: Children; Dogs; Exposure pathway; Lead exposure; Source apportionment.