Fmoc-diphenylalanine gelating nanoarchitectonics: A simplistic peptide self-assembly to meet complex applications

Yunxiao Wang; Qiang Geng; Yan Zhang; Lihi Adler-Abramovich; Xinyuan Fan; Deqing Mei; Ehud Gazit; Kai Tao

doi:10.1016/j.jcis.2022.12.166

Fmoc-diphenylalanine gelating nanoarchitectonics: A simplistic peptide self-assembly to meet complex applications

J Colloid Interface Sci. 2023 Apr 15:636:113-133. doi: 10.1016/j.jcis.2022.12.166. Epub 2023 Jan 3.

Authors

Yunxiao Wang¹, Qiang Geng², Yan Zhang³, Lihi Adler-Abramovich⁴, Xinyuan Fan⁵, Deqing Mei⁶, Ehud Gazit⁷, Kai Tao⁸

Affiliations

¹ State Key Laboratory of Fluid Power and Mechatronic Systems, School of Mechanical Engineering, Zhejiang University, Hangzhou 310027, China; Hangzhou Global Scientific and Technological Innovation Center, Zhejiang University, Hangzhou 311200, China; Zhejiang-Israel Joint Laboratory of Self-Assembling Functional Materials, Hangzhou 311200, China.
² State Key Laboratory of Fluid Power and Mechatronic Systems, School of Mechanical Engineering, Zhejiang University, Hangzhou 310027, China; Hangzhou Global Scientific and Technological Innovation Center, Zhejiang University, Hangzhou 311200, China.
³ Centre for Bioengineering and Biotechnology, College of Chemical Engineering, China University of Petroleum (East China), 66 Changjiang West Road, Qingdao 266580, China.
⁴ Department of Oral Biology, The Goldschleger School of Dental Medicine, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel; The Center for Nanoscience and Nanotechnology, Tel Aviv University, Tel Aviv 6997801, Israel; Zhejiang-Israel Joint Laboratory of Self-Assembling Functional Materials, Hangzhou 311200, China. Electronic address: lihiA@tauex.tau.ac.il.
⁵ State Key Laboratory of Fluid Power and Mechatronic Systems, School of Mechanical Engineering, Zhejiang University, Hangzhou 310027, China; Key Laboratory of Advanced Manufacturing Technology of Zhejiang Province, School of Mechanical Engineering, Zhejiang University, Hangzhou 310027, China; Zhejiang-Israel Joint Laboratory of Self-Assembling Functional Materials, Hangzhou 311200, China.
⁶ State Key Laboratory of Fluid Power and Mechatronic Systems, School of Mechanical Engineering, Zhejiang University, Hangzhou 310027, China; Key Laboratory of Advanced Manufacturing Technology of Zhejiang Province, School of Mechanical Engineering, Zhejiang University, Hangzhou 310027, China.
⁷ The Shmunis School of Biomedicine and Cancer Research, George S. Wise Faculty of Life Sciences, Tel Aviv University, 6997801 Tel Aviv, Israel; Department of Materials Science and Engineering, Iby and Aladar Fleischman, Tel Aviv University, 6997801 Tel Aviv, Israel; Zhejiang-Israel Joint Laboratory of Self-Assembling Functional Materials, Hangzhou 311200, China. Electronic address: ehudg@post.tau.ac.il.
⁸ State Key Laboratory of Fluid Power and Mechatronic Systems, School of Mechanical Engineering, Zhejiang University, Hangzhou 310027, China; Hangzhou Global Scientific and Technological Innovation Center, Zhejiang University, Hangzhou 311200, China; Key Laboratory of Advanced Manufacturing Technology of Zhejiang Province, School of Mechanical Engineering, Zhejiang University, Hangzhou 310027, China; Zhejiang-Israel Joint Laboratory of Self-Assembling Functional Materials, Hangzhou 311200, China. Electronic address: kai.tao@zju.edu.cn.

PMID: 36623365
DOI: 10.1016/j.jcis.2022.12.166

Abstract

9-fluorenylmethoxycarbonyl-diphenylalanine (Fmoc-FF), has been has been extensively explored due to its ultrafast self-assembly kinetics, inherent biocompatibility, tunable physicochemical properties, and especially, the capability of forming self-sustained gels under physiological conditions. Consequently, various methodologies to develop Fmoc-FF gels and their corresponding applications in biomedical and industrial fields have been extensively studied. Herein, we systemically summarize the mechanisms underlying Fmoc-FF self-assembly, discuss the preparation methodologies of Fmoc-FF hydrogels, and then deliberate the properties as well as the diverse applications of Fmoc-FF self-assemblies. Finally, the contemporary shortcomings which limit the development of Fmoc-FF self-assembly are raised and the alternative solutions are proposed, along with future research perspectives.

MeSH terms

Dipeptides* / chemistry
Hydrogels / chemistry
Peptides* / chemistry
Phenylalanine / chemistry

Substances

diphenylalanine
Dipeptides
Peptides
Hydrogels
Phenylalanine