Research progress on the structure and biological diversities of 2-phenylindole derivatives in recent 20 years

Bioorg Chem. 2023 Mar:132:106342. doi: 10.1016/j.bioorg.2023.106342. Epub 2023 Jan 4.

Abstract

The privileged structure binds to multiple receptors with high affinity, which is helpful to the development of new bioactive compounds. Indole is classified as a privileged structure, which may be one of the most important structural categories in drug discovery. As a special subset of indole compounds, 2-phenylindole seems to be one of most promising forerunners of drug development. In this paper, 106 articles were referenced to review the structural changes, biological activities and structure-activity relationship of compounds in recent 20 years, and classified them according to their pharmacological activities, from several aspects, including anticancer, antibacterial, anti-inflammatory, analgesic, antiviral, anti-parasite, the biological activities target to central nervous system, et al. It also points out the importance of artificial intelligence (AI) technology in discovery of new 2-phenylindole compounds in a broader prospect. This review will provide some ideas for researchers to develop new indole drugs.

Keywords: 2-Phenylindole derivatives; Biological activity; SAR.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents* / pharmacology
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology
  • Artificial Intelligence*
  • Indoles / chemistry
  • Indoles / pharmacology
  • Structure-Activity Relationship

Substances

  • 2-phenylindole
  • Anti-Bacterial Agents
  • Indoles
  • Anti-Inflammatory Agents, Non-Steroidal