Abnormal Levels of Serum Ferroptosis-Related Biomarkers in Diabetic Retinopathy

Lin Mu; Dahu Wang; Zhiguo Dong; Jiajun Wu; Xiaoyu Wu; Jing Su; Yinjian Zhang

doi:10.1155/2022/3353740

Abnormal Levels of Serum Ferroptosis-Related Biomarkers in Diabetic Retinopathy

J Ophthalmol. 2022 Dec 30:2022:3353740. doi: 10.1155/2022/3353740. eCollection 2022.

Authors

Lin Mu¹, Dahu Wang¹, Zhiguo Dong¹, Jiajun Wu¹, Xiaoyu Wu¹, Jing Su¹, Yinjian Zhang¹

Affiliation

¹ Department of Ophthalmology, Longhua Hospital Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Abstract

Purpose: This study aimed to measure the concentrations of ferroptosis-related biomarkers, namely, iron (Fe), lipid peroxide (LPO), reactive oxygen species (ROS), glutathione peroxidase-4 (GPX4), and glutathione (GSH) in DR in the attempt to evaluate the diagnostic performance of these biomarkers.

Methods: This study included 30 NPDR patients, 30 PDR patients, and 30 healthy subjects matched in age and sex. The concentrations of Fe, LPO, ROS, GPX4, and GSH in serum of the subjects were measured.

Results: Compared with the normal group, GPX4 and GSH concentrations were significantly lower, and LPO, Fe, and ROS concentrations were significantly higher in DR patients. Compared with the PDR group, the NPDR group had higher concentrations of LPO, Fe, and ROS and lower concentrations of GPX4 and GSH, but there was no statistical difference in Fe, GPX4, and GSH. ROC curve shows that ferroptosis-related biomarkers have accumulated accuracy in NPDR and PDR.

Conclusion: This study shows that ferroptosis-related biomarkers may be involved in the pathological process of DR and can be used as one of the biomarkers of DR.