Fabrication of Bio-Based Film Comprising Metal Oxide Nanoparticles Loaded Chitosan for Wound Dressing Applications

Latifah Mohammed Ali Almaieli; Mai M Khalaf; Mohamed Gouda; Abraham Elmushyakhi; Manal F Abou Taleb; Hany M Abd El-Lateef

doi:10.3390/polym15010211

Fabrication of Bio-Based Film Comprising Metal Oxide Nanoparticles Loaded Chitosan for Wound Dressing Applications

Polymers (Basel). 2022 Dec 31;15(1):211. doi: 10.3390/polym15010211.

Authors

Latifah Mohammed Ali Almaieli¹, Mai M Khalaf^{1

2}, Mohamed Gouda¹, Abraham Elmushyakhi³, Manal F Abou Taleb^{4

5}, Hany M Abd El-Lateef^{1

2}

Affiliations

¹ Department of Chemistry, College of Science, King Faisal University, Al-Ahsa 31982, Saudi Arabia.
² Chemistry Department, Faculty of Science, Sohag University, Sohag 82524, Egypt.
³ Department of Mechanical Engineering, College of Engineering, Northern Border University, Arar 91431, Saudi Arabia.
⁴ Department of Chemistry, College of Science and Humanities, Prince Sattam Bin Abdulaziz University, Al-kharj 11942, Saudi Arabia.
⁵ Department of Polymer Chemistry, National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority, Nasr City, P.O. Box 7551, Cairo 11762, Egypt.

Abstract

In the current work, chitosan (CS)-metal oxide nanohybrid (MONH) composites are prepared via combining CS with MONH made of vanadium oxide (V₂O₅), ytterbium trioxide (Yb₂O₃), and graphene oxide (GO) to generate promising wound dressing materials using the film-casting method. The developed nanohybrid@CS was examined using techniques such as Fourier-transform infrared spectroscopy (FTIR), X-ray powder diffraction (XRD), scanning electron microscopy (SEM)/energy-dispersive X-ray spectroscopy (EDX), and thermogravimetric analysis (TGA). For Yb₂O₃@CS, the surface morphology was shown to be a rough and porous surface with pores that ranged in size from 3.0 to 5.0 µm. For CS with Yb₂O₃, Yb₂O₃/V₂O₅@CS, and Yb₂O₃/V₂O₅/GO@CS, the contact angles were 72.5°, 68.2°, and 46.5°, respectively. When the nanohybrid@CS was in its hydrophilic phase, which is good for absorbing moisture and drugs, there was a notable decrease in angles that tended to rise. Additionally, the inclusion of MONH allowed the cell viability to be confirmed with an IC₅₀ of 1997.2 g/mL and the cell growth to reach 111.3% at a concentration of 7.9 g/mL.

Keywords: biomedical applications; chitosan; metal oxide nanohybrid; polymer nanocomposites; wound dressing.

Grants and funding

FC-2201049/Sohag University