Research Progress and Direction of Novel Organelle-Migrasomes

Yu Zhang; Minghui Zhang; Zhuoyi Xie; Yubo Ding; Jialu Huang; Jingwei Yao; Yufan Lv; Jianhong Zuo

doi:10.3390/cancers15010134

Research Progress and Direction of Novel Organelle-Migrasomes

Cancers (Basel). 2022 Dec 26;15(1):134. doi: 10.3390/cancers15010134.

Authors

Yu Zhang¹, Minghui Zhang¹, Zhuoyi Xie¹, Yubo Ding², Jialu Huang¹, Jingwei Yao², Yufan Lv², Jianhong Zuo^{1

2

3}

Affiliations

¹ The Laboratory of Translational Medicine, Hengyang Medical School, University of South China, 28 Changsheng Road, Hengyang 421001, China.
² Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang 421002, China.
³ Clinical Laboratory, The Third Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang 421900, China.

Abstract

Migrasomes are organelles that are similar in structure to pomegranates, up to 3 μm in diameter, and contain small vesicles with a diameter of 50-100 nm. These membranous organelles grow at the intersections or tips of retracting fibers at the back of migrating cells. The process by which cells release migrasomes and their contents outside the cell is called migracytosis. The signal molecules are packaged in the migrasomes and released to the designated location by migrasomes to activate the surrounding cells. Finally, the migrasomes complete the entire process of information transmission. In this sense, migrasomes integrate time, space, and specific chemical information, which are essential for regulating physiological processes such as embryonic development and tumor invasion and migration. In this review, the current research progress of migrasomes, including the discovery of migrasomes and migracytosis, the structure of migrasomes, and the distribution and functions of migrasomes is discussed. The migratory marker protein TSPAN4 is highly expressed in various cancers and is associated with cancer invasion and migration. Therefore, there is still much research space for the pathogenesis of migratory bodies and cancer. This review also makes bold predictions and prospects for the research directions of the combination of migrasomes and clinical applications.

Keywords: cell migration; migracytosis; migrasome; organelle; tumor.

Publication types

Review

Grants and funding

This research was funded by National Nature Science Foundation of China (82173008); Natural Science Foundation of Hunan Province, China (2022JJ30515); the Key Research Program from the Science and Technology Department of Ningxia Hui Autonomous Region, China (2019BFH02012); the Key Research Program of Hunan Health Committee (20201909); the Program of Hengyang science and Technology Bureau (2017-1, 2020-67); and the Program of Shaoyang Science and Technology Bureau (2018FJ19); the 4310 Program of Hengyang Medical College, University of South China (20224310NHYCG12).