Anti-Oxidant and Pro-Oxidant Effects of Peroxiredoxin 6: A Potential Target in Respiratory Diseases

Wenhui Jia; Chunling Dong; Bo Li

doi:10.3390/cells12010181

Anti-Oxidant and Pro-Oxidant Effects of Peroxiredoxin 6: A Potential Target in Respiratory Diseases

Cells. 2023 Jan 1;12(1):181. doi: 10.3390/cells12010181.

Authors

Wenhui Jia¹, Chunling Dong¹, Bo Li^{1

2}

Affiliations

¹ Department of Pulmonary and Critical Care Medicine, Second Hospital, Jilin University, Changchun 130041, China.
² Jilin Provincial Key Laboratory of Oral Biomedical Engineering, Department of Oral Anatomy and Physiology, Hospital of Stomatology, Jilin University, Changchun 130021, China.

Abstract

Peroxiredoxin 6 (PRDX6) is widely distributed in several organs, especially the lungs. The role of PRDX6 in oxidative stress is controversial and even contradictory, as indicated by research conducted over the past 20 years. PRDX6 has anti-oxidant or pro-oxidant effects on oxidative stress in different diseases. It can even exhibit both anti-oxidant and pro-oxidant effects in the same disease. These findings are attributed to the fact that PRDX6 is a multifunctional enzyme. The peroxidase and phospholipase A2 activity of PRDX6 is closely related to its anti-oxidant and pro-oxidant effects, which leads to the conflicting regulatory effects of PRDX6 on oxidative stress in respiratory diseases. Moreover, PRDX6 interacts with multiple redox signaling pathways to interfere with cell proliferation and apoptosis. PRDX6 has become a new target in respiratory disease research due to its important regulatory role in oxidative stress. In this paper, the role of PRDX6 in oxidative stress in respiratory diseases and the research progress in targeting PRDX6 are reviewed.

Keywords: acute lung injury; anti-oxidant; lung cancer; oxidative stress; peroxiredoxin 6; reactive oxygen species.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Antioxidants* / metabolism
Humans
Oxidative Stress
Peroxiredoxin VI / metabolism
Reactive Oxygen Species / metabolism
Respiratory Tract Diseases*

Substances

Reactive Oxygen Species
Antioxidants
Peroxiredoxin VI

Grants and funding

This research was funded by the National Key Research and Development Program of China (2021YFC2500702); Natural Science Foundation Project from Jilin Provincial Department of Science and Technology (20200201329JC); Outstanding Young and Middle-aged Backbone Talents Project from the Jilin Province Department of Finance (JCSZ2019378-14); Special Health Project from the Jilin Province Department of Finance (2020SCZT023, 3D5177713429); Natural Science Foundation Project from the Department of Science & Technology of Liaoning Province (2021-MS-175); Science and Technology Project from Health Commission of Jilin Province (2015Z007); and Bethune Planned Research project from Jilin University (2018B27).