Single-cell Transcriptomics Reveal the Importance of Distinct Epithelial Cell Populations in Ileal-specific, Treatment-naïve, and Treated Crohn's Disease Patients

Inflamm Bowel Dis. 2023 Feb 1;29(2):334-336. doi: 10.1093/ibd/izac264.
No abstract available

Keywords: Crohn’s disease atlas; cell technologies; ileal-specific Crohn’s disease; single.

Plain language summary

The advent of single-cell technologies has revolutionized analyses of IBD-specific processes by identifying important, often novel, mucosal cells subpopulations and their associated functions. We discuss recent findings reporting transcriptomic and cellular diversity of treatment-naïve and treated patients with ileal-specific CD.

Publication types

  • Editorial
  • Comment

MeSH terms

  • Crohn Disease* / genetics
  • Epithelial Cells
  • Humans
  • Ileum
  • Mucous Membrane
  • Transcriptome