Sweet splicing

Cell. 2023 Jan 5;186(1):10-11. doi: 10.1016/j.cell.2022.11.025.

Abstract

Glucose is the main source of energy for cells. In this issue of Cell, a study now shows that glucose has additional non-energetic functions, acting as a biomolecular cue that regulates alternative splicing during epidermal differentiation. As keratinocytes differentiate, glucose associates with RNA-binding protein DDX21 and modulates its interaction properties, which modifies splicing decisions.

Publication types

  • Comment

MeSH terms

  • Alternative Splicing*
  • Cell Differentiation
  • Glucose
  • RNA Splicing*
  • RNA-Binding Proteins / genetics
  • RNA-Binding Proteins / metabolism

Substances

  • RNA-Binding Proteins
  • Glucose