Optical fibers are the core elements for various fiber-optic applications in communication, lasers, sensors, tweezers, quantum optics, and bio-photonics. Current optical fibers are based on a core-cladding structure with different refractive indices and are mainly fabricated using the stack-draw method. However, such a traditional fabrication method limits the realization of fibers with various advanced optical materials, thereby restricting the utilization of excellent optical properties offered by these materials. In this study, a novel structure for side-array cladding by laser drilling on the side of the fiber with homogeneous material is proposed. Accordingly, the confinement loss, mode characteristics, birefringence, and dispersion of the side-array cladding fiber are investigated based on the numerical simulation performed via the finite element method. Subsequently, an optimal fiber structure is obtained by taking the crystal material as an example. Essentially, our proposed side-array cladding fiber can eliminate the mismatch problem of core-cladding materials in the current stack-draw fabrication method. Potentially, the proposed approach can serve as a standard design and fabrication method of optical fibers with homogeneous material, by utilizing the rapid development of laser processing. In other words, a large number of advanced optical materials can be fabricated into optical fibers with the proposed technique, thus maximizing their technical advantages for different applications.