Biotic communities inspired proteinosome-based aggregation for enhancing utilization rate of enzyme

Xiaoliang Wang; Yan Huang; Yu Ren; Shengliang Wang; Junbo Li; Youping Lin; Haixu Chen; Lei Wang; Xin Huang

doi:10.1016/j.jcis.2022.12.132

Biotic communities inspired proteinosome-based aggregation for enhancing utilization rate of enzyme

J Colloid Interface Sci. 2023 Apr:635:456-465. doi: 10.1016/j.jcis.2022.12.132. Epub 2022 Dec 28.

Authors

Xiaoliang Wang¹, Yan Huang¹, Yu Ren¹, Shengliang Wang¹, Junbo Li¹, Youping Lin¹, Haixu Chen¹, Lei Wang¹, Xin Huang²

Affiliations

¹ MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage, School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150001, China.
² MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage, School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150001, China. Electronic address: xinhuang@hit.edu.cn.

PMID: 36599243
DOI: 10.1016/j.jcis.2022.12.132

Abstract

Compared with the individuals, the collective behavior of biotic communities could show certain superior characteristics. Inspired by this idea and based on the conjugation between phenylboronic acid-grafted mesoporous silica nanoparticles and the polysaccharide functionalized membrane of proteinosomes, a type of proteinosomes-based aggregations was constructed. We demonstrated the emergent characteristics of proteinosomes aggregations including accelerated settling velocity and population surviving by sacrificing outside members for the inside. Moreover, this kind of "hand in hand" architecture provided the proteinosomes aggregations with the characteristic of resistance to the negative pressure phagocytosis of micropipette, as well as enhancing utilization rate of the encapsulated enzymes. Overall, it is anticipated that the construction and application of proteinosomes aggregations could contribute to advance the functionality of life-like assembled biomaterial in another way.

Keywords: Biomimetic material; Collective behavior; Enzyme immobilization; Proteinosome aggregations.