Complete Genome Sequence of Nocardia iowensis DSM 45197T (= NRRL 5646T)

Aneisha Collins Fairclough; Cathrin Spröer; Jolantha Swiderski; Boyke Bunk; Andrew S Lamm

doi:10.1128/mra.00581-22

Complete Genome Sequence of Nocardia iowensis DSM 45197^T (= NRRL 5646^T)

Microbiol Resour Announc. 2023 Jan 24;12(1):e0058122. doi: 10.1128/mra.00581-22. Epub 2023 Jan 4.

Authors

Aneisha Collins Fairclough¹, Cathrin Spröer^{2

3}, Jolantha Swiderski^{2

3}, Boyke Bunk², Andrew S Lamm¹

Affiliations

¹ Natural Products Research Laboratory, Faculty of Science and Sport, University of Technology, Kingston, Jamaica.
² Leibniz Institute DSMZ-German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany.
³ German Centre of Infection Research, Partner Site Hannover-Braunschweig, Braunschweig, Germany.

Abstract

We report the complete genome sequence and predicted functional profile of Nocardia iowensis DSM 45197^T. N. iowensis DSM 45197^T is a spore-forming, mesophilic, Gram-positive bacterium that was isolated from garden soil in Osceola, Iowa, USA. This organism has been exploited for its production of glycocinnamolyspermidine antibiotics and biotransformation of xenobiotic substances. Other significant features of N. iowensis DSM 45197^T include the first fully characterized carboxylic acid reductase (CAR) and the first bacterial nitric oxide synthase system. The genome sequence of N. iowensis DSM 45197^T can facilitate further understanding of its function, as well as the pathogenesis of Nocardia spp. N. iowensis DSM 45197^T has a genome size of 8.95 Mbp; about 46% of the coding sequences have no known homologues and were labeled hypothetical proteins. This finding implies further potential for biomedical and biotechnological research applications.