Yixue Qiyuan is a representative work of Yuansu Zhang, a famous medical scientist during the Jin Dynasty. The contents of Five Yun and Six Qi are quite rich, especially the discussion on the treatment prescription and medication of Six Qi, which has a significant impact on the development of traditional Chinese medicine. Therefore, analyzing his drug rules and summarizing his medical thoughts can provide a reference for the clinical application of the theory of Five Yun and Six Qi. Based on the TCM inheritance auxiliary platform (V2.5), the data analyzed 63 first prescriptions and 134 drugs contained in the six Qi prescription sections of Yixue Qiyuan. Based on the frequency analysis, correlation rule analysis, four qi and five flavors, and meridian analysis, the formula rules for wind, summer heat, wet soil, fire, dryness, and cold water were obtained, and medical thought was summarized. Drug rules of prescription and medical thought can provide a useful reference for the classical study of traditional Chinese medicine and the application of the Six Qi theory in clinical practice.
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