Early Life Reprogramming-Based Treatment Promotes Longevity

Patrizia Pessina; Bruno Di Stefano

doi:10.1089/cell.2022.0153

Early Life Reprogramming-Based Treatment Promotes Longevity

Cell Reprogram. 2023 Feb;25(1):9-10. doi: 10.1089/cell.2022.0153. Epub 2022 Dec 30.

Authors

Patrizia Pessina^{1

2

3

4}, Bruno Di Stefano^{1

2

3

4}

Affiliations

¹ Stem Cells and Regenerative Medicine Center, Baylor College of Medicine, Houston, Texas, USA.
² Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas, USA.
³ Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA.
⁴ Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas, USA.

Abstract

Short-term expression of Yamanaka factors early in life promotes epigenetic reprogramming and an increased healthy lifespan in a mouse model of accelerated aging.

Keywords: aging; epigenetic clock; rejuvenation; reprogramming.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Aging / genetics
Animals
Cellular Reprogramming*
Epigenesis, Genetic
Longevity*
Mice
Rejuvenation

Grants and funding

R35 GM147126/GM/NIGMS NIH HHS/United States