Salicylaldehyde (SA) derivatives are emerging as useful fragments to obtain reversible-covalent inhibitors interacting with the lysine residues of the target protein. Here the SA installation at the C terminus of an integrin-binding cyclopeptide, leading to enhanced ligand affinity for the receptor as well as stronger biological activity in cultured glioblastoma cells is reported.
Keywords: aldehydes; cell adhesion; covalent inhibitors; integrins; peptidomimetics.
© 2023 The Authors. Chemistry - A European Journal published by Wiley-VCH GmbH.