Commentary on why implementing and standardizing histologic diagnosis of myocarditis is crucial for the clinical setting and patient care

Gregory A Fishbein; Ornella Leone; Cristina Basso; John T Fallon; Karin Klingel; Carmela Tan

doi:10.1016/j.carpath.2022.107515

Commentary on why implementing and standardizing histologic diagnosis of myocarditis is crucial for the clinical setting and patient care

Cardiovasc Pathol. 2023 May-Jun:64:107515. doi: 10.1016/j.carpath.2022.107515. Epub 2022 Dec 31.

Authors

Gregory A Fishbein¹, Ornella Leone², Cristina Basso³, John T Fallon⁴, Karin Klingel⁵, Carmela Tan⁶

Affiliations

¹ Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA. Electronic address: gfishbein@mednet.ucla.edu.
² Department of Pathology, Cardiovascular and Cardiac Transplant Pathology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy. Electronic address: ornella.leone@aosp.bo.it.
³ Cardiovascular Pathology, Department of Cardiac, Thoracic and Vascular Sciences and Public Health, University Hospital of Padua, Padua, Italy.
⁴ Department of Pathology and Laboratory Medicine, Brody School of Medicine at East Carolina University, Greenville, NC, USA.
⁵ Cardiopathology, Institute for Pathology University Hospital Tübingen, Tübingen, Germany.
⁶ Department of Pathology, Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH, USA.

PMID: 36592720
DOI: 10.1016/j.carpath.2022.107515

Abstract

Histological examination of endomyocardial biopsy or myocardium at autopsy is key to the diagnosis of myocarditis. Among pathologists there is currently extensive variability in routine practice and criteria used to define, diagnose, and report myocarditis as well as to achieve consensus on cases. Two manuscripts emphasizing the need to standardize and implement histopathological diagnostic criteria for myocarditis are reviewed.

Keywords: Dallas criteria; Histologic criteria; Inflammation; Myocarditis.

MeSH terms

Autopsy
Biopsy
Humans
Myocarditis* / diagnosis
Myocarditis* / pathology
Myocardium / pathology
Patient Care