Case report: Durable response after pembrolizumab in combination with radiation - induced abscopal effect in platinum - refractory metastatic endometrial clear cell carcinoma

Chien-Hsiang Kao; Chien-Ting Liu; Hao Lin; Yung-Cheng Huang; Jui Lan; Yu-Che Ou; Hung-Chun Fu; Chen-Hsuan Wu

doi:10.3389/fimmu.2022.1079253

Case report: Durable response after pembrolizumab in combination with radiation - induced abscopal effect in platinum - refractory metastatic endometrial clear cell carcinoma

Front Immunol. 2022 Dec 15:13:1079253. doi: 10.3389/fimmu.2022.1079253. eCollection 2022.

Authors

Chien-Hsiang Kao¹, Chien-Ting Liu², Hao Lin¹, Yung-Cheng Huang³, Jui Lan⁴, Yu-Che Ou^{1

5}, Hung-Chun Fu¹, Chen-Hsuan Wu^{1

6}

Affiliations

¹ Department of Obstetrics and Gynecology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.
² Division of Hematology-Oncology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University, College of Medicine, Kaohsiung, Taiwan.
³ Department of Nuclear Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University, College of Medicine, Kaohsiung, Taiwan.
⁴ Department of Anatomic Pathology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.
⁵ Department of Obstetrics and Gynecology, Chia-Yi Chang Gung Memorial Hospital, Chia-Yi, Taiwan.
⁶ Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan.

Abstract

Advanced endometrial clear cell carcinoma (CCC) tends to have poor prognosis owing to aggressive clinical behavior and poor response to conventional chemotherapy. Herein, we report a case of platinum-refractory recurrent ECCC successfully treated with the combination of pembrolizumab, localized radiotherapy and a few cycles of chemotherapy with an extremely durable response even after cessation of immunotherapy for 3 years at the time of publication.

Keywords: ARID1A; PD-L1; abscopal effect; clear cell carcinoma; endometrial cancer; immunotherapy; pembrolizumab; radiotherapy.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Antibodies, Monoclonal, Humanized / therapeutic use
Carcinoma* / drug therapy
Female
Humans
Platinum
Uterine Neoplasms* / drug therapy

Substances

pembrolizumab
Platinum
Antibodies, Monoclonal, Humanized