Pancancer analysis of SKA1 mutation and its association with the diagnosis and prognosis of human cancers

Hua Lan; Jing Yuan; Rui Zhang; Biyao Jiang; Qiaofen Li; Zongyan Huang; Peiling Chen; Huimin Xiang; Xiangyang Zeng; Songshu Xiao

doi:10.1016/j.ygeno.2022.110554

Pancancer analysis of SKA1 mutation and its association with the diagnosis and prognosis of human cancers

Genomics. 2023 Mar;115(2):110554. doi: 10.1016/j.ygeno.2022.110554. Epub 2022 Dec 30.

Authors

Hua Lan¹, Jing Yuan², Rui Zhang³, Biyao Jiang⁴, Qiaofen Li⁴, Zongyan Huang⁴, Peiling Chen⁴, Huimin Xiang⁴, Xiangyang Zeng⁵, Songshu Xiao⁶

Affiliations

¹ Department of Gynecology and Obstetrics, Third Xiangya Hospital, Central South University, Changsha, Hunan, China; Department of Gynecology and Obstetrics, Changsha Central Hospital of University of South China, Changsha, Hunan, China.
² Department of Gynecology and Obstetrics, Third Xiangya Hospital, Central South University, Changsha, Hunan, China; Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
³ Department of Gynecology and Obstetrics, Third Xiangya Hospital, Central South University, Changsha, Hunan, China; Department of Oncology, Huaihua Hospital of University of South China, Huaihua, Hunan, China.
⁴ Department of Gynecology and Obstetrics, Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
⁵ Department of Gynecology and Obstetrics, Third Xiangya Hospital, Central South University, Changsha, Hunan, China. Electronic address: zengxiangyang@csu.edu.cn.
⁶ Department of Gynecology and Obstetrics, Third Xiangya Hospital, Central South University, Changsha, Hunan, China. Electronic address: xiaosongshu@csu.edu.cn.

PMID: 36587749
DOI: 10.1016/j.ygeno.2022.110554

Abstract

This study aims to explore the role of SKA1 in cancer diagnosis and prognosis and to investigate the mechanism by which SKA1 affects the malignant behaviors of ovarian cancer. Herein, we analyzed the oncogenic role of SKA1 at pan-cancer level by multiple informatics databases and verified the analysis by in vitro experiments. As a result, SKA1 was upregulated across cancers and was related to poor clinical outcome and immune infiltration. Specifically, the constructed nomogram showed superior performance in predicting the prognosis of epithelial ovarian cancer patients. Furthermore, the in vitro experiments revealed that silencing SKA1 significantly inhibited the proliferation, migratory ability and enhanced the cisplatin sensitivity of ovarian cancer cells. Therefore, we explored the oncogenic and potential therapeutic role of SKA1 across cancers through multiple bioinformatic analysis and revealed that SKA1 may promote ovarian cancer progression and chemoresistance to cisplatin by activating the AKT-FOXO3a signaling pathway.

Keywords: Comprehensive bioinformatics; Nomograph; Ovarian cancer; Prognostic value; SKA1.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Chromosomal Proteins, Non-Histone / genetics
Chromosomal Proteins, Non-Histone / metabolism
Cisplatin* / pharmacology
Cisplatin* / therapeutic use
Female
Humans
Ovarian Neoplasms* / diagnosis
Ovarian Neoplasms* / genetics
Prognosis
Signal Transduction

Substances

Cisplatin
SKA1 protein, human
Chromosomal Proteins, Non-Histone