Risk factors of cytokine release syndrome: stress, catecholamines, and beyond

Xiaoyan Xing; Xiaoyu Hu

doi:10.1016/j.it.2022.12.003

Risk factors of cytokine release syndrome: stress, catecholamines, and beyond

Trends Immunol. 2023 Feb;44(2):93-100. doi: 10.1016/j.it.2022.12.003. Epub 2022 Dec 30.

Authors

Xiaoyan Xing¹, Xiaoyu Hu²

Affiliations

¹ Institute for Immunology and School of Medicine, Tsinghua University, Beijing, 100084, China.
² Institute for Immunology and School of Medicine, Tsinghua University, Beijing, 100084, China; Beijing Key Laboratory for Immunological Research on Chronic Diseases, Beijing, 100084, China; Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing, 100084, China. Electronic address: xiaoyuhu@tsinghua.edu.cn.

PMID: 36586780
DOI: 10.1016/j.it.2022.12.003

Abstract

Cytokine release syndrome (CRS) is a severe clinical syndrome marked by drastic elevation of inflammatory cytokines such as interleukin (IL)-1, IL-6, and tumor necrosis factor (TNF). Despite the current empirical therapeutic strategies, prediction of CRS onset and identification of high-risk individuals are not satisfactory due to poor understanding of the mechanisms underlying CRS-related immune dysfunction and risk factors for CRS. Recent studies have suggested that conditions such as stress, obesity, diabetes, and hypertension may contribute to the development of CRS. Here, we discuss potential connections between these conditions and CRS pathogenesis, with a focus on stress hormone catecholamine-mediated effects, hoping that the design of CRS therapeutic approaches ensues from a renewed perspective.

Keywords: catecholamine; cytokine release syndrome; diabetes; hypertension; obesity; proinflammatory status.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Catecholamines* / therapeutic use
Cytokine Release Syndrome*
Cytokines
Humans
Risk Factors

Substances

Catecholamines
Cytokines

Associated data

ChiCTR/ChiCTR2000029765