Dendritic cells in energy balance regulation

Ana Redondo-Urzainqui; Elena Hernández-García; Emma Clare Laura Cook; Salvador Iborra

doi:10.1016/j.imlet.2022.12.002

Dendritic cells in energy balance regulation

Immunol Lett. 2023 Jan:253:19-27. doi: 10.1016/j.imlet.2022.12.002. Epub 2022 Dec 29.

Authors

Ana Redondo-Urzainqui¹, Elena Hernández-García¹, Emma Clare Laura Cook², Salvador Iborra³

Affiliations

¹ Department of Immunology, Ophthalmology and ENT, School of Medicine, Universidad Complutense de Madrid, Madrid, 28040, Spain.
² Department of Immunology, Ophthalmology and ENT, School of Medicine, Universidad Complutense de Madrid, Madrid, 28040, Spain. Electronic address: eccook@cnic.es.
³ Department of Immunology, Ophthalmology and ENT, School of Medicine, Universidad Complutense de Madrid, Madrid, 28040, Spain. Electronic address: siborra@ucm.es.

PMID: 36586424
DOI: 10.1016/j.imlet.2022.12.002

Abstract

Besides their well-known role in initiating adaptive immune responses, several groups have studied the role of dendritic cells (DCs) in the context of chronic metabolic inflammation, such as in diet-induced obesity (DIO) or metabolic-associated fatty liver disease. DCs also have an important function in maintaining metabolic tissue homeostasis in steady-state conditions. In this review, we will briefly describe the different DC subsets, the murine models available to assess their function, and discuss the role of DCs in regulating energy balance and maintaining tissue homeostasis.

Keywords: Adipose tissue; Dendritic cells; Flt3l, cDC1; Homeostasis; Obesity.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Dendritic Cells
Homeostasis
Immunity, Humoral
Inflammation* / metabolism
Mice
Obesity*