Mesenchymal stem cells for regenerative medicine in central nervous system

Man Li; Hong Chen; Mingxin Zhu

doi:10.3389/fnins.2022.1068114

Mesenchymal stem cells for regenerative medicine in central nervous system

Front Neurosci. 2022 Dec 13:16:1068114. doi: 10.3389/fnins.2022.1068114. eCollection 2022.

Authors

Man Li¹, Hong Chen¹, Mingxin Zhu²

Affiliations

¹ Department of Anesthesia, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
² Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Abstract

Mesenchymal stem cells (MSCs) are multipotent stem cells, whose paracrine and immunomodulatory potential has made them a promising candidate for central nervous system (CNS) regeneration. Numerous studies have demonstrated that MSCs can promote immunomodulation, anti-apoptosis, and axon re-extension, which restore functional neural circuits. The therapeutic effects of MSCs have consequently been evaluated for application in various CNS diseases including spinal cord injury, cerebral ischemia, and neurodegenerative disease. In this review, we will focus on the research works published in the field of mechanisms and therapeutic effects of MSCs in CNS regeneration.

Keywords: anti-apoptosis; central nervous system; immunomodulation; mesenchymal stem cells (MeSH ID D059630); regenerative medicine.

Publication types

Review