Dataset of dual RNA-seq mapping in visceral leishmaniasis: Inquiry on parasite transcripts in human blood transcriptome upon Leishmania infantum infection

Ellen Gomes; Luana Aparecida Rogerio; Nayore Tamie Takamiya; Caroline Torres; João Santana da Silva; Roque Pacheco Almeida; Sandra Regina Maruyama

doi:10.1016/j.dib.2022.108811

Dataset of dual RNA-seq mapping in visceral leishmaniasis: Inquiry on parasite transcripts in human blood transcriptome upon Leishmania infantum infection

Data Brief. 2022 Dec 8:46:108811. doi: 10.1016/j.dib.2022.108811. eCollection 2023 Feb.

Authors

Ellen Gomes¹, Luana Aparecida Rogerio¹, Nayore Tamie Takamiya¹, Caroline Torres¹, João Santana da Silva², Roque Pacheco Almeida³, Sandra Regina Maruyama¹

Affiliations

¹ Department of Genetics and Evolution, Center for Biological Sciences and Health, Federal University of São Carlos, São Carlos, Brazil.
² Fiocruz-Bi-Institutional Translational Medicine Platform, Ribeirão Preto, Brazil.
³ Department of Medicine, University Hospital-Empresa Brasileira de Serviços Hospitalares (EBSERH), Federal University of Sergipe, Aracaju, Brazil.

Abstract

This dataset is related to the article "Insight Into the Long Noncoding RNA and mRNA Coexpression Profile in the Human Blood Transcriptome Upon Leishmania infantum Infection" by S.R. Maruyama, C.A. Fuzo, A.E.R. Oliveira, L.A. Rogerio, N.T. Takamiya, G. Pessenda, E.V. de Melo, A.M. da Silva, A.R. Jesus, V. Carregaro, H.I. Nakaya, R.P. Almeida and J.S. da Silva. Frontiers in Immunology, 2022. Through the reuse of raw sequencing data, we generated original dataset by performing a dual RNA-seq mapping procedure to survey the parasite transcripts found in RNA-seq samples from blood of visceral leishmaniasis patients. Diseased patients with active infection displayed the highest number of reads mapped to L. infantum genome. Even after six months later of the treatment, when the patients were considered cured, parasite reads were still detected. Parasite reads were also detected in asymptomatic individuals. The original dual RNA-seq alignment read count data provided here can be further explored to evaluate either host or parasite transcripts.

Keywords: Dual RNA-seq; Host/parasite interaction; Leishmania; Leishmaniasis; blood transcriptomics.