Meta-analysis of the relation between irritable bowel syndrome and antibodies against endogenous gonadotropin-releasing hormone and its receptor

Karam R Motawea; Joseph Varney; Mohamed Gamal; Kirellos Said Abbas; Fatma A Monib; Mhd Kutaiba Albuni; Elias Battikh; Bisher Sawaf; Lina Taha Khairy; Agyad Bakkour; Ali Hadi Hussein Muwaili; Fatima Abubaker Abdalla Abdelmajid; Eman Mohammed Sharif Ahmed; Dhuha Hadi Hussein Muwaili; Safaa M A Ahmed; Sarya Swed

doi:10.1080/08998280.2022.2093588

Meta-analysis of the relation between irritable bowel syndrome and antibodies against endogenous gonadotropin-releasing hormone and its receptor

Proc (Bayl Univ Med Cent). 2022 Jul 13;36(1):61-65. doi: 10.1080/08998280.2022.2093588. eCollection 2023.

Authors

Karam R Motawea¹, Joseph Varney², Mohamed Gamal³, Kirellos Said Abbas¹, Fatma A Monib⁴, Mhd Kutaiba Albuni⁵, Elias Battikh⁵, Bisher Sawaf⁶, Lina Taha Khairy⁷, Agyad Bakkour⁸, Ali Hadi Hussein Muwaili⁹, Fatima Abubaker Abdalla Abdelmajid¹⁰, Eman Mohammed Sharif Ahmed¹¹, Dhuha Hadi Hussein Muwaili⁹, Safaa M A Ahmed¹², Sarya Swed¹³

Affiliations

¹ Faculty of Medicine, Alexandria University, Egypt.
² American University of the Caribbean School of Medicine, Sint Maarten.
³ Faculty of Medicine, Tanta University, Egypt.
⁴ Faculty of Medicine, Assiut University, Egypt.
⁵ Department of Internal Medicine, Damascus University, Damascus, Syria.
⁶ Department of Internal Medicine, Syrian Private University, Damascus, Syria.
⁷ The National Ribat University, Al-Ribat, Sudan.
⁸ Faculty of Medicine, Albaath University, Homs, Syria.
⁹ Ivano-Frankivsk National Medical University, Ukraine.
¹⁰ University of Medical Sciences and Technology, Sudan.
¹¹ Nile Vally University, Atbra, Sudan.
¹² Faculty of Medicine, Shendi University, Sudan.
¹³ Faculty of Medicine, Aleppo University, Aleppo, Syria.

Abstract

This meta-analysis assessed the association between gonadotropin hormone-releasing hormone (GnRH) antibodies and irritable bowel syndrome (IBS). We defined a search strategy and implemented it with PubMed, Ovid, Scopus, and Web of Science databases for English language publications. The data were evaluated for acceptability, and randomized controlled studies as well as case-control, cross-sectional, and cohort studies reporting the prevalence of GnRH antibodies in IBS patients were included. The total number of patients in the included studies was 1095: 270 patients in the IBS group and 825 patients in the control group. By comparing the IBS group and the control group, we found a statistically significant association between IBS and the increased prevalence of GnRH IgM antibodies (risk ratio = 2.29, 95% confidence interval = 1.58 to 3.31, P < 0.0001). We also found a statistically significant association between IBS and increased prevalence of GnRH receptor IgM antibodies compared with controls (risk ratio = 3.80, 95% confidence interval = 1.72 to 8.38, P = 0.001). The meta-analysis revealed a statistically significant association between IBS and increased prevalence of GnRH IgM and GnRH receptor IgM antibodies.

Keywords: Endogenous gonadotropin-releasing hormone; GnRH antibodies; irritable bowel syndrome; metaanalysis.

Publication types

Review