In North Carolina, USA, the SARS-CoV-2 Omicron variant was associated with changing symptomology in daily surveys, including increasing rates of self-reported cough and sore throat and decreased rates of loss of taste and smell. Compared with the pre-Delta period, Delta and Omicron (pre-BA.4/BA.5) variant periods were associated with shorter symptom duration.
Trial registration: ClinicalTrials.gov NCT04342884.
Keywords: COVID-19; North Carolina; SARS-CoV-2; United States; coronavirus disease; respiratory infections; severe acute respiratory syndrome coronavirus 2; surveillance; symptoms; viruses; zoonoses.