Echinacoside exerts its protective effects in a type 2 diabetes mellitus injury model via the AKT pathway

Wei-Wei Ye; Xiang-Ying Meng; Qian Zhao; Jian-Yang Chen; Cong Liu; Feng Chen; Yong Zhou; Yi Wang

doi:10.1080/10286020.2022.2157269

Echinacoside exerts its protective effects in a type 2 diabetes mellitus injury model via the AKT pathway

J Asian Nat Prod Res. 2023 Sep;25(9):880-889. doi: 10.1080/10286020.2022.2157269. Epub 2022 Dec 27.

Authors

Wei-Wei Ye¹, Xiang-Ying Meng¹, Qian Zhao¹, Jian-Yang Chen¹, Cong Liu¹, Feng Chen¹, Yong Zhou¹, Yi Wang¹

Affiliation

¹ Department of Endocrinology, Dahua Hospital, Shanghai 200237, China.

PMID: 36573490
DOI: 10.1080/10286020.2022.2157269

Abstract

Echinacoside (ECH) is the main compound of Cistanche deserticola, which possesses antioxidant, antitumor, antifatigue, and anti-inflammatory properties. The present study investigated the protective effects of echinacoside on type 2 diabetes mellitus (T2DM)-induced injury in T2DM injury db/db mice model and insulin-resistant LO₂ cell model. The results demonstrated that ECH probably alleviated T2DM-induced injury by mediating the AKT pathway, which provided a new direction for the treatment of T2DM-induced injury.

Keywords: AKT; ECH; T2DM; glucose; insulin resistance.

MeSH terms

Animals
Antioxidants
Diabetes Mellitus, Type 2* / drug therapy
Glycosides / pharmacology
Mice
Proto-Oncogene Proteins c-akt* / metabolism

Substances

Proto-Oncogene Proteins c-akt
echinacoside
Glycosides
Antioxidants