Cell Sheet Technology as an Engineering-Based Approach to Bone Regeneration

Qi You; Minxun Lu; Zhuangzhuang Li; Yong Zhou; Chongqi Tu

doi:10.2147/IJN.S382115

Cell Sheet Technology as an Engineering-Based Approach to Bone Regeneration

Int J Nanomedicine. 2022 Dec 20:17:6491-6511. doi: 10.2147/IJN.S382115. eCollection 2022.

Authors

Qi You^#^{1

2}, Minxun Lu^#^{1

2}, Zhuangzhuang Li^{1

2}, Yong Zhou^{1

2}, Chongqi Tu^{1

2}

Affiliations

¹ Orthopedic Research Institute, Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, Sichuan Province, People's Republic of China.
² Sichuan Model Worker and Craftsman Talent Innovation Research Studio, Chengdu, Sichuan Province, People's Republic of China.

^# Contributed equally.

Abstract

Bone defects that are congenital or the result of infection, malignancy, or trauma represent a challenge to the global healthcare system. To address this issue, multiple research groups have been developing novel cell sheet technology (CST)-based approaches to promote bone regeneration. These methods hold promise for use in regenerative medicine because they preserve cell-cell contacts, cell-extracellular matrix interactions, and the protein makeup of cell membranes. This review introduces the concept and preparation system of the cell sheet (CS), explores the application of CST in bone regeneration, highlights the current states of the bone regeneration via CST, and offers perspectives on the challenges and future research direction of translating current knowledge from the lab to the clinic.

Keywords: bone defect; bone regeneration; bone tissue engineering; cell sheet technology.

Publication types

Review

MeSH terms

Bone Regeneration
Extracellular Matrix
Regenerative Medicine*
Technology
Tissue Engineering*

Grants and funding

The work was supported by the Science and Technology Research Program of Sichuan Province (2020YFS0036), QingDao research institutes of SiChuan University, Research of biomedical materials and 3D printing related products (20GZ30301), China postdoctoral Science Foundation (2021M702342) and 1·3·5 project for disciplines of excellence, West China Hospital, Sichuan University (ZYJC18017).