Effect of Standing Intravenous Acetaminophen on Postoperative Opioid Exposure in a Pediatric Cardiac Intensive Care Unit

Chelsea M Torres; Andrew S Geneslaw; Leanne Svoboda; Arthur J Smerling; Katherine R Schlosser Metitiri

doi:10.1016/j.jpeds.2022.12.003

Effect of Standing Intravenous Acetaminophen on Postoperative Opioid Exposure in a Pediatric Cardiac Intensive Care Unit

J Pediatr. 2023 Apr:255:236-239.e2. doi: 10.1016/j.jpeds.2022.12.003. Epub 2022 Dec 23.

Authors

Chelsea M Torres¹, Andrew S Geneslaw², Leanne Svoboda³, Arthur J Smerling², Katherine R Schlosser Metitiri²

Affiliations

¹ Department of Pediatrics, Columbia University Irving Medical Center, New York-Presbyterian Morgan Stanley Children's Hospital, New York, NY; Division of General Academic Pediatrics, Department of Pediatrics, University of South Florida, Tampa, FL. Electronic address: ctorres2@usf.edu.
² Division of Critical Care and Hospital Medicine, Department of Pediatrics, Columbia University Irving Medical Center, New York-Presbyterian Morgan Stanley Children's Hospital, New York, NY.
³ Department of Pharmacy, New York-Presbyterian Morgan Stanley Children's Hospital, New York, NY.

PMID: 36572175
DOI: 10.1016/j.jpeds.2022.12.003

Abstract

This study assessed the association between standing intravenous acetaminophen and opioid exposure after cardiac surgery. Before vs after implementation of a standardized pain pathway, we report decreased opioid exposure, 0.38 milligram per kilogram of morphine equivalents [IQR 0.10-0.81] vs 0.26 milligram per kilogram of morphine equivalents [0.09-0.56] (P = .01) and increased acetaminophen exposure, 3 [2-4] vs 4 [4-5] doses (P < .001).

Keywords: cardiac surgery; multimodal analgesia; opioid-sparing.

Publication types

Case Reports

MeSH terms

Acetaminophen* / adverse effects
Analgesics, Non-Narcotic* / adverse effects
Analgesics, Opioid / adverse effects
Child
Humans
Intensive Care Units, Pediatric
Morphine / therapeutic use
Pain, Postoperative / drug therapy

Substances

Acetaminophen
Analgesics, Opioid
Morphine
Analgesics, Non-Narcotic