Facile Synthesis of TiO2-SiO2-P2O5/CaO/ZnO with a Core-Shell Structure for Bone Implantation

Ekaterina S Lyutova; Valeriya A Tkachuk; Liliya A Selyunina; Lyudmila P Borilo; Dmitriy A Fedorishin; Yu-Wen Chen

doi:10.1021/acsomega.2c05398

Facile Synthesis of TiO₂-SiO₂-P₂O₅/CaO/ZnO with a Core-Shell Structure for Bone Implantation

ACS Omega. 2022 Dec 7;7(50):46564-46572. doi: 10.1021/acsomega.2c05398. eCollection 2022 Dec 20.

Authors

Ekaterina S Lyutova¹, Valeriya A Tkachuk¹, Liliya A Selyunina¹, Lyudmila P Borilo¹, Dmitriy A Fedorishin¹, Yu-Wen Chen²

Affiliations

¹ National Research Tomsk State University, 36 Lenina Avenue, Tomsk634050, Russia.
² Department of Chemical and Materials Engineering, National Central University, Jhongli32001, Taiwan.

Abstract

A facile synthesis method was developed to synthesize TiO₂-SiO₂-P₂O₅/CaO or TiO₂-SiO₂-P₂O₅/ZnO with a core-shell structure. The carboxylic cation exchanger Tokem-250 has a high selectivity for Ca²⁺/Zn²⁺ ions and was used in this study. The framework of the material in the shell was TiO₂-SiO₂-P₂O₅, and the inner part was filled with CaO (sample TiO₂-SiO₂/CaO) or ZnO (sample TiO₂-SiO₂-P₂O₅/ZnO). A stepwise heat treatment (drying in a drying oven at 60 °C for 30 min, then annealing in a muffle furnace for 30 min at 150, 250, and 350 °C, at 600 °C for 6 h, and at 800 °C for 1 h) was needed to obtain a homogeneous material. The poly(vinyl alcohol) was used as a binding additive. The obtained composites were characterized by a regular structure and highly developed surface. The samples exhibit bioactive properties in the simulated body fluid (SBF) solution, since the surface contains active centers (Si⁴⁺, Ti⁴⁺) which contribute to mineralization and precipitation of the calcium-phosphate compounds on the surface from biological media. The TiO₂-SiO₂-P₂O₅/CaO-PVA samples did not exceed acceptable hemolysis levels for medical materials.