Case report: Nocardia gipuzkoensis infection in an immunocompetent patient diagnosed by metagenomic next-generation sequencing and whole genome sequencing

Chengxin Liu; Juhua Yang; Huiting Huang; Shaofeng Zhan; Xintian Xia

doi:10.3389/fimmu.2022.1053914

Case report: Nocardia gipuzkoensis infection in an immunocompetent patient diagnosed by metagenomic next-generation sequencing and whole genome sequencing

Front Immunol. 2022 Dec 9:13:1053914. doi: 10.3389/fimmu.2022.1053914. eCollection 2022.

Authors

Chengxin Liu^{1

2}, Juhua Yang³, Huiting Huang², Shaofeng Zhan², Xintian Xia²

Affiliations

¹ The First Clinical Medical School, Guangzhou University of Chinese Medicine, Guangzhou, China.
² The First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, China.
³ Vision Medicals Co., Ltd., Guangzhou, China.

Abstract

The infection of Nocardia gipuzkoensis is a relatively uncommon form of pulmonary nocardiosis seen in clinical patients. In general, nocardiosis tends to occur in patients with immune deficiency. Here, we report a 23-year-old female who was admitted to the hospital due to cough and sputum production over 10 years, diagnosed with bronchiectasis. The N. gipuzkoensis infection was identified by metagenomic next-generation sequencing and whole genome sequencing. Imipenem/cilastatin and compound sulfamethoxazole tablets were used to control the infection and the pulmonary inflammation subsided gradually.

Keywords: antibiotic susceptibility; case report; metagenomic next-generation sequencing; nocardiosis; pathogen identification; whole genome sequencing.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Female
High-Throughput Nucleotide Sequencing
Humans
Nocardia Infections* / diagnosis
Nocardia Infections* / drug therapy
Nocardia* / genetics
Sulfamethoxazole / therapeutic use
Whole Genome Sequencing
Young Adult

Substances

Sulfamethoxazole