Luminescent polyelectrolytes with antiviral activity

E F Panarin; A I Fischer; N A Nesterova; A A Shtro; A V Dobrodumov; I I Gavrilova; V A Manakhov; T N Nekrasova

doi:10.1007/s11172-022-3662-4

Luminescent polyelectrolytes with antiviral activity

Russ Chem Bull. 2022;71(11):2352-2357. doi: 10.1007/s11172-022-3662-4. Epub 2022 Dec 19.

Authors

E F Panarin¹, A I Fischer^{1

2}, N A Nesterova¹, A A Shtro³, A V Dobrodumov¹, I I Gavrilova¹, V A Manakhov³, T N Nekrasova¹

Affiliations

¹ Institute of Macromolecular Compounds, Russian Academy of Sciences, 31 Bol'shoy prosp. V. O., 199004 St. Petersburg, Russian Federation.
² St. Petersburg State Institute of Technology (Technical University), 26 Moskovskiy prosp., 190013 St. Petersburg, Russian Federation.
³ A. A. Smorodintsev Research Institute of Influenza, Ministry of Health of the Russian Federation, 15/17 ul. prof. Popova, 197376 St. Petersburg, Russian Federation.

Abstract

Radical polymerization was used to synthesize and characterize (co)polymers with sodium styrenesulfonate (NaSS), 4-methacryloylamidosalicylic acid (MASA), and N-vinylpyrrolidone, which have a low cytotoxicity and a high antiviral activity against the human respiratory syncytial virus. The interaction of copolymers with Tb³⁺ ions was studied. The complexes formed in dilute aqueous solutions at a concentration of MASA units c ⩽ 1 · 10^-4 mol L^-1 demonstrate a strong luminescence. The luminescence intensity is independent of copolymer composition, but increases when the NaSS units are substituted with uncharged N-vinylpyrrolidone units. The obtained Tb³⁺ polymer complexes are promising luminescent sensors for the visualization of biological objects interacting with copolymers.

Keywords: 4-methacryloylamidosalicylic acid; antiviral activity; lanthanides; luminescent metal-polymer complexes; sodium polystyrenesulfonate.