Cardiopulmonary capacity is reduced in children with ventricular arrhythmia

Abstract

Background: Premature ventricular contractions (PVCs) are frequently seen in children and are considered benign. A substantial group of adolescents with PVCs complain about a broad range of clinical symptoms, including low exertion tolerance.

Objective: The purpose of this study was to evaluate prospectively whether ventricular arrhythmia affects physical performance in adolescents with normal left ventricular function, using a cardiopulmonary exercise test (CPET) and evaluating the electrocardiographic (ECG) characteristics of patients with PVCs with regard to exercise capacity.

Methods: The study group consisted of 49 children with PVCs and normal left ventricular function. The control group consisted of 36 healthy volunteers. Standard ECG, 24-hour Holter ECG, and CPET were performed. PVCs were analyzed for QRS duration, bundle branch block pattern, QRS axis, and coupling interval (CInt). For CPET, heart rate (HR), oxygen uptake (VO_2max), predicted VO_2max, and VO_2max expressed as a percentage of the predicted value (%VO₂) were measured.

Results: In 37 patients (76%), arrhythmia subsided during exercise. Patients achieved lower VO_2max (32.9 ± 6.3 mL/min/kg) than controls (40.4 ± 6.7 mL/min/kg; P <.01). %VO₂ was 71.0 ± 13.7 in patients and 79.3 ± 12.2 in controls (P <.01). Exercise HR at which PVCs subsided correlated with VO_2max (r = 0.3; P = .07). Patients with persisting arrhythmia performed worse than those in whom arrhythmia subsided during exercise (VO_2max, P <.01; %VO_2,P <.01). No correlation between QRS and CInt parameters and VO_2max was observed.

Conclusion: Patients with PVCs have lower aerobic capacity than their healthy peers. Further worsening of exercise capacity is present when PVCs are preserved during effort.

Keywords: Adolescents; Arrhythmia subsiding; Exercise capacity; Oxygen uptake; Premature ventricular contraction.