Emerging role of aging in the progression of NAFLD to HCC

Yongyuan He; Yinghong Su; Chengcheng Duan; Siyuan Wang; Wei He; Yingting Zhang; Xiaofei An; Ming He

doi:10.1016/j.arr.2022.101833

Emerging role of aging in the progression of NAFLD to HCC

Ageing Res Rev. 2023 Feb:84:101833. doi: 10.1016/j.arr.2022.101833. Epub 2022 Dec 22.

Authors

Yongyuan He¹, Yinghong Su¹, Chengcheng Duan¹, Siyuan Wang¹, Wei He², Yingting Zhang¹, Xiaofei An³, Ming He⁴

Affiliations

¹ Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Ministry of Education, Shanghai Frontiers Science Center of Cellular Homeostasis and Human Diseases, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
² Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Ministry of Education, Shanghai Frontiers Science Center of Cellular Homeostasis and Human Diseases, Shanghai Jiao Tong University School of Medicine, Shanghai, China; School of Basic Medicine, Kunming Medical University, China.
³ Department of Endocrinology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China. Electronic address: anxiaofei2000@163.com.
⁴ Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Ministry of Education, Shanghai Frontiers Science Center of Cellular Homeostasis and Human Diseases, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Department of Pathology, The Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, China. Electronic address: heming@shsmu.edu.cn.

PMID: 36565959
DOI: 10.1016/j.arr.2022.101833

Abstract

With the aging of global population, the incidence of nonalcoholic fatty liver disease (NAFLD) has surged in recent decades. NAFLD is a multifactorial disease that follows a progressive course, ranging from simple fatty liver, nonalcoholic steatohepatitis (NASH) to liver cirrhosis and hepatocellular carcinoma (HCC). It is well established that aging induces pathological changes in liver and potentiates the occurrence and progression of NAFLD, HCC and other age-related liver diseases. Studies of senescent cells also indicate a pivotal engagement in the development of NAFLD via diverse mechanisms. Moreover, nicotinamide adenine dinucleotide (NAD⁺), silence information regulator protein family (sirtuins), and mechanistic target of rapamycin (mTOR) are three vital and broadly studied targets involved in aging process and NAFLD. Nevertheless, the crucial role of these aging-associated factors in aging-related NAFLD remains underestimated. Here, we reviewed the current research on the roles of aging, cellular senescence and three aging-related factors in the evolution of NAFLD to HCC, aiming at inspiring promising therapeutic targets for aging-related NAFLD and its progression.

Keywords: Aging; HCC; MTOR; NAD(+); NAFLD; Sirtuins.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Aging
Carcinoma, Hepatocellular* / epidemiology
Carcinoma, Hepatocellular* / metabolism
Carcinoma, Hepatocellular* / pathology
Disease Progression
Humans
Liver Neoplasms* / epidemiology
Liver Neoplasms* / metabolism
Liver Neoplasms* / pathology
Non-alcoholic Fatty Liver Disease* / epidemiology
Non-alcoholic Fatty Liver Disease* / metabolism
Non-alcoholic Fatty Liver Disease* / pathology