SGLSA: Sphygmus gated laser speckle angiography for microcirculation hemodynamics imaging

Ximeng Feng; Mufeng Geng; Xiangxi Meng; Da Zou; Zi Jin; Gangjun Liu; Chuanqing Zhou; Qiushi Ren; Yanye Lu

doi:10.1016/j.compmedimag.2022.102164

SGLSA: Sphygmus gated laser speckle angiography for microcirculation hemodynamics imaging

Comput Med Imaging Graph. 2023 Jan:103:102164. doi: 10.1016/j.compmedimag.2022.102164. Epub 2022 Dec 15.

Authors

Ximeng Feng¹, Mufeng Geng¹, Xiangxi Meng², Da Zou³, Zi Jin³, Gangjun Liu³, Chuanqing Zhou⁴, Qiushi Ren¹, Yanye Lu⁵

Affiliations

¹ Institute of Medical Technology, Peking University Health Science Center, Peking University, Beijing, China; Department of Biomedical Engineering, College of Future Technology, Peking University, Beijing, China; National Biomedical Imaging Center, Peking University, Beijing, China; Institute of Biomedical Engineering, Shenzhen Bay Laboratory, Shenzhen, China; Institute of Biomedical Engineering, Peking University Shenzhen Graduate School, Shenzhen, China.
² Key Laboratory of Carcinogenesis and Translational Research, Department of Nuclear Medicine, Peking University Cancer Hospital & Institute, Beijing, China.
³ Institute of Biomedical Engineering, Shenzhen Bay Laboratory, Shenzhen, China; Institute of Biomedical Engineering, Peking University Shenzhen Graduate School, Shenzhen, China.
⁴ College of Medical Instrument, Shanghai University of Medicine and Health Sciences, Shanghai, China.
⁵ Institute of Medical Technology, Peking University Health Science Center, Peking University, Beijing, China; National Biomedical Imaging Center, Peking University, Beijing, China; Institute of Biomedical Engineering, Peking University Shenzhen Graduate School, Shenzhen, China. Electronic address: yanye.lu@pku.edu.

PMID: 36563513
DOI: 10.1016/j.compmedimag.2022.102164

Abstract

Hemodynamics imaging of the retinal microcirculation has been demonstrated to be potential access to evaluating ophthalmic diseases, cardio-cerebrovascular diseases, and metabolic diseases. However, existing structural and functional imaging techniques are insufficient in spatial or temporal resolution. The sphygmus gated laser speckle angiography (SGLSA) is proposed for structural and functional imaging with high spatiotemporal resolution. Compared with classic LSCI algorithms, SGLSA presents a much clearer perfusion image and higher signal-to-noise ratio pulsatility. The SGLSA algorithm also shows better performance on patients than traditional LSCI methods. The high spatiotemporal resolution provided by the SGLSA algorithm greatly enhances the ability of retinal microcirculation analysis, which makes up for the deficiency of the LSCI technology, and attaches great significance to retinal hemodynamic imaging, biomarker research, and clinical diagnosis.

Keywords: Blood flow imaging; Laser speckle contrast imaging; Retinal microcirculation.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Angiography*
Blood Flow Velocity
Hemodynamics*
Humans
Lasers
Microcirculation