Endoplasmic Reticulum Stress in Hepatitis B Virus and Hepatitis C Virus Infection

Tengyue Hu; Jiayi Wang; Weixiu Li; Miao Liu; Ning Han; Man Yuan; Lingyao Du; Hong Tang

doi:10.3390/v14122630

Endoplasmic Reticulum Stress in Hepatitis B Virus and Hepatitis C Virus Infection

Viruses. 2022 Nov 25;14(12):2630. doi: 10.3390/v14122630.

Authors

Tengyue Hu^{1

2}, Jiayi Wang^{1

2}, Weixiu Li^{1

2}, Miao Liu^{1

2}, Ning Han^{1

2}, Man Yuan^{1

2}, Lingyao Du^{1

2}, Hong Tang^{1

2}

Affiliations

¹ Center of Infectious Diseases, West China Hospital of Sichuan University, Chengdu 610041, China.
² Division of Infectious Diseases, State Key Laboratory of Biotherapy and Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu 610041, China.

Abstract

Endoplasmic reticulum (ER) stress, a type of cellular stress, always occurs when unfolded or misfolded proteins accumulating in the ER exceed the protein folding capacity. Because of the demand for rapid viral protein synthesis after viral infection, viral infections become a risk factor for ER stress. The hepatocyte is a cell with large and well-developed ER, and hepatitis virus infection is widespread in the population, indicating the interaction between hepatitis viruses and ER stress may have significance for managing liver diseases. In this paper, we review the process that is initiated by the hepatocyte through ER stress against HBV and HCV infection and explain how this information can be helpful in the treatment of HBV/HCV-related diseases.

Keywords: endoplasmic reticulum stress; hepatitis B virus; hepatitis C virus; unfolded protein response.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Endoplasmic Reticulum Stress
Hepacivirus
Hepatitis B virus*
Hepatitis C*
Humans
Unfolded Protein Response

Grants and funding

This work was supported by the National Natural Science Foundation (Grant No. 82172254), 1.3.5 project for disciplines of excellence, West China Hospital, Sichuan University (Grant No. ZYGD20009), the National Key Research and Development Program of China (2022YFC2304800), and the Sichuan Science and Technology Program (23SYSX0023).