Risk of Malnutrition in Hospitalized COVID-19 Patients: A Systematic Review and Meta-Analysis

Nutrients. 2022 Dec 10;14(24):5267. doi: 10.3390/nu14245267.

Abstract

(1) Background: Studies have reported that COVID-19 may increase the risk of malnutrition among patients. However, the prevalence of such risk in hospitalized COVID-19 patients is uncertain due to the inconsistent use of assessment methods. (2) Methods: PubMed, Web of Science, and EMBASE were searched to identify studies on the nutritional status of hospitalized COVID-19 patients. A pooled prevalence of malnutrition risk evaluated by Nutrition Risk Score (NRS-2002) was obtained using a random effects model. Differences by study-level characteristics were examined by hospitalization setting, time of assessment, age, and country. Risk of bias was assessed using the Newcastle−Ottawa Scale. (3) Results: 53 studies from 17 countries were identified and summarized. A total of 17 studies using NRS-2002, including 3614 COVID-19 patients were included in the primary meta-analysis. The pooled prevalence of risk of malnutrition was significantly higher among ICU patients (92.2%, 95% CI: 85.9% to 96.8%) than among general ward patients (70.7%, 95% CI: 56.4% to 83.2%) (p = 0.002). No significant differences were found between age groups (≥65 vs. <65 years, p = 0.306) and countries (p = 0.893). (4) Conclusions: High risk of malnutrition is common and concerning in hospitalized patients with COVID-19, suggesting that malnutrition screening and nutritional support during hospitalization are needed.

Keywords: hospitalized COVID-19 patients; meta-analysis; prevalence; risk of malnutrition.

Publication types

  • Meta-Analysis
  • Systematic Review
  • Review

MeSH terms

  • COVID-19* / epidemiology
  • Hospitalization
  • Humans
  • Malnutrition* / diagnosis
  • Malnutrition* / epidemiology
  • Malnutrition* / etiology
  • Nutrition Assessment
  • Nutritional Status
  • Nutritional Support / methods
  • Prevalence

Grants and funding

This research received no external funding.