Development of Cell Therapies for Renal Disease and Regenerative Medicine

Int J Mol Sci. 2022 Dec 15;23(24):15943. doi: 10.3390/ijms232415943.

Abstract

The incidence of renal disease is gradually increasing worldwide, and this condition has become a major public health problem because it is a trigger for many other chronic diseases. Cell therapies using multipotent mesenchymal stromal cells, hematopoietic stem cells, macrophages, and other cell types have been used to induce regeneration and provide a cure for acute and chronic kidney disease in experimental models. This review describes the advances in cell therapy protocols applied to acute and chronic kidney injuries and the attempts to apply these treatments in a clinical setting.

Keywords: cell therapies; kidney disease; regenerative therapies; tissue repair.

Publication types

  • Review

MeSH terms

  • Cell- and Tissue-Based Therapy
  • Humans
  • Kidney
  • Mesenchymal Stem Cells*
  • Regenerative Medicine / methods
  • Renal Insufficiency, Chronic* / therapy